Journal: Journal of Pharmacy Research

Article Id: JPRS-SDNS-00002190
Title: In vitro antifungal activity of Pterocarpus marsupium used among tribal communities of Western Ghats, Coimbatore, Tamil Nadu
Category: Screening of drugs from Natural & Synthetic origin
Section: Research Article
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    Background: To investigate the in vitro antifungal activity of Pterocarpus marsupium leaf extracts used in folklore treatments among tribal community in the Western Ghats of Coimbatore district. Methods: The crude aqueous and organic solvent leaf extracts extracted by cold maceration method were subjected to antifungal activity against Aspergillus flavus and Aspergillus fumigatus by agar plate dilution method. Results: The methanol and ethanol leaf extracts of P. marsupium showed significant (P < 0.01) antifungal activity against A. flavus at an minimum inhibitory concentration of 31 µg/mL with IC50 values 114.04 and 169 µg/mL, respectively. Similar antifungal activity of 100% inhibition was exhibited by alcoholic leaf extracts against A. fumigatus. Besides, the chloroform leaf extracts showed 82.94% and 80.58% fungistatic activity against A. fumigatus and A. flavus, respectively. Comparable antifungal activity was also observed in other concentrations of alcoholic and chloroform extracts of P. marsupium against A. flavus and A. fumigatus. The aqueous leaf extract did not show demonstrable antifungal activity against the two fungal strains used in the assay which was not up to the score. Conclusion: The methanolic and ethanolic leaf extracts of selected plants were more active against tested fungal strains when compared to the chloroform and aqueous extracts. Further investigations are mandatory to identify the antifungal compounds present in the chosen herb.

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    Author(s) Name:

    Rangasamy Dhanabalan1* , Subbu Balachandar1 , Joseph Devakumar2

    Affiliation(s) Name:

    1 Department of Microbiology, Rathnavel Subramaniam College of Arts and Science, Coimbatore, Tamil Nadu, India,

    2Department of Microbiology, Dr. N.G.P. Arts and Science College, Coimbatore, Tamil Nadu, India

    *Corresponding author: Dr. Rangasamy Dhanabalan, Department of Microbiology, Rathnavel Subramaniam College of Arts and Science, Coimbatore – 641 402, Tamil Nadu, India.

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    Author:

    Rangasamy Dhanabalan1* , Subbu Balachandar1 , Joseph Devakumar2

    Title:In vitro antifungal activity of Pterocarpus marsupium used among tribal communities of Western Ghats, Coimbatore, Tamil Nadu
    Journal:Journal of Pharmacy Research
    Vol(issue):12 (May)
    Year:2018
    Page No: (697-701)
  • Experimental Methods Keywords

    Methodology:Antifungal activity
    Research Materials: Pterocarpus marsupium

Keywords

Antifungal aspergillosis bronchopulmonary folklore mycosis

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