Journal: Drug Invention Today

Article Id: JPRS-PS-00002205
Title: Radiologic response evaluation after conventional whole-brain radiation therapy plus concurrent oral administration of losartan versus radiation therapy alone in patients with brain metastases
Category: Pharmacological Screening
Section: Research Article
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    Objective: The present study aims to comparatively investigate the radiologic response to conventional whole-brain radiation therapy (WBRT) with and without oral losartan in the patients with brain metastases. Methods: This was a single-blinded clinical trial conducted on patients (n = 60) diagnosed with brain metastasis referred to Golestan Hospital, Ahvaz, Iran, during 2017. The patients were randomly divided into intervention and control groups: The control group was treated with WBRT (30 Gy per 10 fractions over 2 weeks) and the placebo of losartan. The intervention group was treated with WBRT concomitant with oral administration of losartan (25 mg), 1 h before each fraction. To measure the radiologic response rate, brain magnetic resonance imaging (MRI) images were compared before and 6 weeks after treatments in terms of metastasis size according to response evaluation criteria in solid tumor (RECIST V1.1). According to the response evaluation criteria, the patients were divided into four groups: Complete response, partial response, progressive disease, and stable disease. Finally, data were analyzed by Chi-square and regression tests using statistical package of SPSS (version 20, Windows). Results: In the intervention group, 9 cases showed radiological response (complete radiologic response + partial radiologic response), and in the control group, 7 cases had radiologic response, which were not significant (P = 0.20) difference. Conclusion: Administration of losartan simultaneously with WBRT in patients with brain metastasis did not have a significant positive effect on the radiologic response rate.

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    Author(s) Name:

    Seyedmohammad Hosseini 1,2 , Yasamin Mahouram1 *, Shole Arvandi 1 , Samira Razzaghi 1 , Hodjatollah Shahbazian1 , Sasan Razmjoo1 ,Nasim Feizi 1 , Faeze Ebrahimian1

    Affiliation(s) Name:

    1 Department of Clinical Oncology, Golestan Hospital, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran,

    2 Cancar, Petroleum and Environmental Pollutants Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    *Corresponding author: Yasamin Mahouran, Department of Clinical Oncology, Golestan Hospital, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran.

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    Author:

    Seyedmohammad Hosseini 1,2 , Yasamin Mahouram1 *, Shole Arvandi 1 , Samira Razzaghi 1 , Hodjatollah Shahbazian1 , Sasan Razmjoo1 ,Nasim Feizi 1 , Faeze Ebrahimian1

    Title:Radiologic response evaluation after conventional whole-brain radiation therapy plus concurrent oral administration of losartan versus radiation therapy alone in patients with brain metastases
    Journal:Drug Invention Today
    Vol(issue):10 (April)
    Year:2018
    Page No: (575-579)
  • Experimental Methods Keywords

    Methodology:clinical trial, brain metastasis,data analysis
    Research Materials:Losartan

Keywords

Brain metastasis Losartan Radiation therapy

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