Journal: Journal of Pharmacy Research

Article Id: JPRS-PC-0000221
Title: Synthesis of Novel Hetero Cyclic Dithiocarbamate Metal Complexes and Study of their Biological Activity
Category: Pharmaceutical Chemistry
Section: Research Article
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    Dithiocarbamates (DTC) are well known compounds to bind strongly and selectively to many metal ions, so in the past few years self-assembly directed by metal–dithiocarbamate coordination has emerged as a useful supramolecular methodology for the preparation of macrocycles, cages, catenanes, and nanoparticles. Most of the applications are based on complexation properties of DTC ligands with metal ions, especially with transition metal ions. DTC ligands readily form chelates with all transition metal ions through its two donor sulfur atoms. In the present investigation carried out a synthesis of as such new dithiocarbamates derived from unique series of heterocyclic amines, 4 –amino 1,2,4-triazole ,2-amino-3-hydroxy pyridine, 3-amino-9-ethyl carbazole, furfryl amine and 2-amino-4-hydroxy-6-methyl pyrimidine with Carbon disulphide, and characterized using elemental analyses, FT-IR, NMR. The antibacterial activities of synthesized compounds were studied against two Gram-negative species, Escherichia coli, Klebsiella pneumoniae and one Gram-positive species, Bacillus subtilis.

    Cite this article as: K. Venugopal, A. Jayaraju and J. Sreeramulu*,Synthesis of Novel Hetero Cyclic Dithiocarbamate Metal Complexes and Study of their Biological Activity,Journal of Pharmacy Research 2015,9(2),125-128

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    Author(s) Name:

    K. Venugopal, A. Jayaraju and J. Sreeramulu*

    Affiliation(s) Name:

    Dept. of Chemistry, Sri Krishnadevaraya University, Anantapur-515003, A.P., India

     

    *Corresponding author.
    K.Venugopal
    Dept. of Chemistry,
    Sri Krishnadevaraya University,
    Anantapur-515003, A.P., India


    Received on:24-11-2014; Revised on: 19-12-2014; Accepted on:13-02-2015

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    Author:

    K. Venugopal, A. Jayaraju and J. Sreeramulu*

    Title:Synthesis of Novel Hetero Cyclic Dithiocarbamate Metal Complexes and Study of their Biological Activity
    Journal:Journal of Pharmacy Research
    Vol(issue):9 (February)
    Year:2015
    Page No: (125-128)
  • Experimental Methods Keywords

    Methodology:Synthesis and Biological activity
    Research Materials:Dithiocarbamate metal complexes

Keywords

Synthesis Dithiocarbamate metal complexes characterization Antibacterial activity

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