Journal: Journal of Pharmacy Research

Article Id: JPRS-PSPA-00002212
Title: In vitro antibacterial activities of the methanolic and aqueous extracts of Moringa stenopetala leaves
Category: Phytochemical Study and Pharmacological Activity
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    Objective: The extensive and multiple antibiotics resistant to microbial strains are due to reduced susceptibility to antibiotics, hypersensitivity, and immune suppression. These conditions are forced scientists to search for new antimicrobial agents from medicinal plants. The present study was aimed to evaluate the in vitro antimicrobial potential of methanolic and aqueous leave extract of Moringa stenopetala, from Shire Endaslassie (SE) and Abi-Addi (AA) from Tigray region, Ethiopia. Methods: About 50 g of the plant powder was subjected to maceration and decoction extractions using methanol and aqueous as solvent, respectively, and the extracts were filtered and it was kept in refrigerator at 4°C until analysis. The in vitro antibacterial activity of methanolic and aqueous leaves extract of M. stenopetala was evaluated against three Gram- negative bacteria and two Gram-positive bacteria by agar well diffusion method. Results: The results of the present study was indicated that methanolic extract of M. stenopetala from SE and AA showed the most promising broad-spectrum antibacterial activity against both Gram-negative and Gram-positive bacteria by exhibiting maximum inhibition zone diameters, while aqueous leave extract of M. stenopetala shown moderate and no activity on all the tested organisms. Conclusion: The potent antimicrobial activity of methanolic extract of M. stenopetala has the presence of broad-spectrum antibiotic compound in the extracts. The medicinal plant M. stenopetala is a potential candidate for the development of plant-derived antibacterial compounds for the treatment of bacterial infections.

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    Author(s) Name:

    Zenebe Hagos1 *, M. Zenebe Teka2 , M. Yirga Brhane1 , K. Krishna Chaithanya1 , V. K. Gopalakrishnan1 , Tesfay Weletnsae1

    Affiliation(s) Name:

    1 Department of Chemistry, College of Natural and Computational Sciences, Aksum University, Axum, Ethiopia,

    2 Department of Biology, College of Natural and Computational Sciences, Aksum University, Axum, Ethiopia

    *Corresponding author: Zenebe Hagos, Department of Chemistry, College of Natural and Computational Sciences, Aksum University, Tigray Region, Post Box No: 1010, Axum, Ethiopia.

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    Author:

    Zenebe Hagos1 *, M. Zenebe Teka2 , M. Yirga Brhane1 , K. Krishna Chaithanya1 , V. K. Gopalakrishnan1 , Tesfay Weletnsae1

    Title:In vitro antibacterial activities of the methanolic and aqueous extracts of Moringa stenopetala leaves
    Journal:Journal of Pharmacy Research
    Vol(issue):12(5)
    Year:2018
    Page No: (788-793)
  • Experimental Methods Keywords

    Methodology:Agar well diffusion, Antimicrobial agents, Medicinal plants, Multiple Drug Resistance, Zone of inhibition
    Research Materials:Moringa stenopetala leaves

Keywords

Agar well diffusion Antimicrobial agents Medicinal plants Multiple Drug Resistance Zone of inhibition

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