Journal: Drug Invention Today

Article Id: JPRS-CDRS-00002221
Title: Impact of lifestyle and environment on melatonin hormone in relation to oxidative stress
Category: Clinical Drugs Related Study
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    Background: Melatonin hormone secretion affected by the type and conditions of sleep. Its act as antioxidant and has a major role in different biochemical process in human body. The aim of the present study is that to determine the effect of lifestyle (time of sleep, exposure to sunlight, and physical activity) on melatonin levels and oxidative stress markers in groups which differ in their lifestyle and activity. Materials and Methods: Three groups participate in the study; Group 1 consists of 30 volunteers selected from an agricultural rural community, Group 2 includes 30 volunteers selected from army forces works at a checkpoint, and Group 3 includes 30 volunteers from medical staff (doctors and nurses) in Al-Yarmok Teaching Hospital. Blood was drawing from all volunteers in the morning (8:00–10:00 AM). Melatonin levels and oxidative stress markers were measured. Results: Melatonin hormone level shows significant increase (P ˃ 0.05) in rural environment when compared to other studied environment. The mean of glutathione significantly increase (P ˃ 0.05) in Group 1 when compared to both Groups 2 and 3, but there was no significant difference between Groups 2 and 3. Serum malondialdehyde significantly increases in Group 3 when compared to other studied groups (P ˃ 0.05). Conclusions: The difference in lifestyle was effected on melatonin level which acts as antioxidant and also on oxidative stress markers. Melatonin levels increase in the subjects who lived in the rural environment which exposure to sunlight and exert more effort due to their work in agriculture as compared to subjects who work in army in checkpoint and the two populations more than the 3rd group which include medical staff who work at night shift.

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    Author(s) Name:

    Huda Jaber Waheed1 *, Amaal Rasheed Farhan2 , Perry Habeeb Saifullah3

    Affiliation(s) Name:

    1 Department of Clinical Laboratory Science, College of Pharmacy, Al-Mustansiriyah University, Iraq,

    2 Department of Chemistry, Institute of Medical Technology, Baghdad, Iraq,

    3 Department of Chemistry, College of Science for Women, Baghdad University, Iraq

    *Corresponding author: Huda Jaber Waheed, Department of Clinical Laboratory Science, College of Pharmacy, Al-Mustansiriyah University, Iraq.

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    Author:

    Huda Jaber Waheed1 *, Amaal Rasheed Farhan2 , Perry Habeeb Saifullah3

    Title:Impact of lifestyle and environment on melatonin hormone in relation to oxidative stress
    Journal:Drug Invention Today
    Vol(issue):9 (December)
    Year:2017
    Page No: (121-125)
  • Experimental Methods Keywords

    Methodology:oxidative stress
    Research Materials:Melatonin

Keywords

Free radical Lifestyle Melatonin Oxidative stress Sleep

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