Journal: Journal of Pharmacy Research

Article Id: JPRS-P'Col-0000223
Title: Evaluation of Cissampelos pareira root for antifertility activity
Category: Pharmacology
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    Bacground: The practice of traditional medicine for the control of fertility in most parts of India is based on the uses of plant medicines for many years. Cissampelos pareira Linn. is one of the folk medicinal plants commonly used as antifertility agent in some places of India. Objective: The aim of the present study was to evaluate the antifertility effect of the methanolic extract of Cissampelos pareira root with mechanism of action. Methods: The methanolic extract of Cissampelos pareira root were investigated for its effect on estrous cycle, effect on implantation and reproductive hormones in female rats at two oral dose level: 250 mg/kg and 500 mg/kg. Serum estradiol and progesterone level were estimated by ELISA method. Serums were isolated from blood samples collected on 12th, 19th, and 21st day of pregnancy.Results: No significant effect on extending the estrous cycle has been found with methanolic extracts of Cissampelos pareira root [CPR] treated group as compared to control group. Reduction in the number of implants in CPR treated group is significant. Furthermore, there is no significant change in serum estradiol and progesterone level from day 12th to 19th in CPR treated groups as compared to control group. Conclusion: All these observations suggest that CPR neither has any effect on extending the estrous cycle nor on implantation. We may conclude that alkaloids, the chief chemical constituent, present in CPR has no role in regulating the fertility.

    Cite this article as:Jhuma Samanta , Dr. Snehendu Bhattacharya, Dr.Avtar Chand Rana,Evaluation of Cissampelos pareira root for antifertility activity,Journal of Pharmacy Research 2015,9(2),134-138.

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    Author(s) Name:

    Jhuma Samanta 1*, Dr. Snehendu Bhattacharya2, Dr.Avtar Chand Rana3

    Affiliation(s) Name:

    1. Rayat and Bahra Institute of Pharmacy, Sahauran, Kharar, Mohali, Punjab, India
    2. Global Institute of Pharmaceutical Education and Research, Kashipur, Uttarakhand, India.
    3. Institute of Pharmaceutical Sciences. Kurukshetra University, Kurukshetra, Haryana, India

    *Corresponding author.
    Ms. Jhuma Samanta
    Rayat & Bahra Institute of Pharmacy,
    Sahauran, Kharar, Punjab, India.


    Received on:24-12-2014; Revised on: 18-01-2015; Accepted on:29-02-2015

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    Author:

    Jhuma Samanta 1*, Dr. Snehendu Bhattacharya2, Dr.Avtar Chand Rana3

    Title:Evaluation of Cissampelos pareira root for antifertility activity
    Journal:Journal of Pharmacy Research
    Vol(issue):9(2)
    Year:2015
    Page No: (134-138)
  • Experimental Methods Keywords

    Methodology:Phytochemical screening,Pharmacological Screening ,estrous cycle, implantation ,reproductive hormones
    Research Materials:Cissampelos pareira

Keywords

Antifertility effect; Estrus cycle; Female rats; Cissampelos pareira root methanolic extract [CPR];

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