Journal: Drug Invention Today

Article Id: JPRS-Pcol-00002268
Title: A detailed study on the function of neutrophils and macrophages in periodontitis
Category: Pharmacology
Section: Research Article
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    Introduction: Periodontitis is highly complex and multifactorial disease. The reasons for periodontal illnesses are microorganism. The human oral cavity harbors a significant and persistently developing heap of microbial species. The natural cooperations between the host and organisms decide the seriousness of the ailment. Experimental evidences confirm that certain bacterial strains in periodontal environment can induce gingival tissue inflammation and bone destruction. The pathogenesis of periodontal illnesses is intervened by the fiery reaction to microscopic organisms in the dental biofilm. Materials and Methods: The study population consisted of aggressive periodontitis (n = 3), juvenile periodontitis (n = 3), and healthy individuals (n = 3) with no systemic or oral diseases. Determination of interleukin (IL)-17, and neutrophil infiltration and monocyte clustering were determined. Results: Neutrophil infiltration or disruption exhibited by adult periodontitis was greater when compared to juvenile periodontitis. There was an increased expression of IL-17 in juvenile periodontitis when compared to adult periodontitis. Conclusion: In light of the outcomes, it can be reasoned that the neutrophil infiltration in adult periodontitis is greater when compared to juvenile periodontitis whereas the IL-17 expression is greater in juvenile periodontitis on comparison with healthy and adult periodontitis.

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    Author(s) Name:

    M. Amina1 , R. Gayathri 2 *, V. Vishnu Priya2

    Affiliation(s) Name:

    1 Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Science, Saveetha University, Chennai, Tamil Nadu, India,

    2 Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Science, Saveetha University, Chennai, Tamil Nadu, India

    *Corresponding author: R. Gayathri, Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Science, Saveetha University, 160, Poonamallee High Road, Chennai - 600 077, Tamil Nadu, India

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    Author:

    M. Amina1 , R. Gayathri 2 *, V. Vishnu Priya2

    Title:A detailed study on the function of neutrophils and macrophages in periodontitis
    Journal:Drug Invention Today
    Vol(issue):10 (June)
    Year:2018
    Page No: (848-852)
  • Experimental Methods Keywords

    Methodology:Function, Immune mediators, Pathogenesis
    Research Materials:Periodontitis

Keywords

Function Immune mediators Pathogenesis Periodontitis

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