Journal: Drug Invention Today

Article Id: JPRS-Pcol-00002276
Title: Evaluation of inflammatory markers in endotoxins induced root canal infection
Category: Pharmacology
Section: Research Article
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    Aim: The aim of this study is to evaluate the inflammatory markers in endotoxins induced root canal infection. Introduction: Root canal infection is mainly caused by an opportunistic infection of the pulp space with commensal oral microorganisms. Depending on the state of inflammation, different treatment regimes are currently advocated. The role of several players of the host response in root canal infection is as follows: Cytokines, proteases, inflammatory mediators, growth factors, antimicrobial peptides, and others contribute to pulpal defense mechanisms; these factors may serve as biomarkers that indicate the status of the pulp. Endotoxins are potent inflammatory agents, which activate classical and alternative pathways of complement system. Materials and Methods: The sterility of the internal surface of the access cavity was checked and all procedures were performed aseptically to the study participants. A new sterile and apyrogenic bur were used accomplished by irrigation with sterile apyrogenic water to access the canal. The endotoxin sample was taken introducing sterile pyrogen-free paper points into the full length of the canal and retained in position during 60 s. Immediately, the paper point was placed in a pyrogen-free glass and at 80°C for future cell culture stimulation. Results: C-reactive protein (CRP) shows agglutination for endotoxin group when compared to that of apyrogenic group. The mean value of fibrinogen in serum of endotoxin-induced group was 400 mg/dl which was found to be higher than apyrogenic group. The level of inflammatory markers such as CRP, fibrinogen, and uric acid was significantly high (P < 0.001) in serum sample. Our results suggest that inflammatory marker significantly increases in patients and correlates with infection severity. Conclusion: The pathogenesis of root canal infection is accepted widely to involve inflammation. Hence, dental practitioners should have concerns that root canal treatment may provide a source of inflammation and increase the risk of treatment failure.

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    Author(s) Name:

    G. Karthiga Devi 1 , V. Vishnu Priya2 *, R. Gayathri 2

    Affiliation(s) Name:

    1 Department of  Biochemistry, Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India,

    2 Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India

    *Corresponding author: V. Vishnu Priya, Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India

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    Author:

    G. Karthiga Devi 1 , V. Vishnu Priya2 *, R. Gayathri 2

    Title:Evaluation of inflammatory markers in endotoxins induced root canal infection
    Journal:Drug Invention Today
    Vol(issue):10 (June)
    Year:2018
    Page No: (887-891)
  • Experimental Methods Keywords

    Methodology:C-reactive protein, Fibrinogen, Inflammatory markers, Root canal infection, Uric acid
    Research Materials:Root canal infection

Keywords

C-reactive protein Fibrinogen Inflammatory markers Root canal infection Uric acid

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