Journal: Drug Invention Today

Article Id: JPRS-BRPT-00002296
Title: Applications of gene therapy in dentistry - a review
Category: Biotechnology & Related Pharmaceutical Technology
Section: Review Article
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    Change and modification is a continuous process in the advancement of technology. Research is being done to understand the cellular and molecular basis of every disease. In research facilities around the world, scientists are attempting to prevent diseases at their very roots. Most of the conventional methods to treat disease are not giving satisfactory results. Instead of curing illness and diseases with drugs, they are trying to modify the genes that cause the diseases. Genes are specific sequences of bases that encode instruction to make proteins. Genetic disorder results when these genes are altered, and their encoded proteins are unable to carry their normal functions. Gene therapy involves the transfer of new genetic material or transformation of the existing material for treating human diseases. Gene therapy is designed to introduce genetic materials into the cell to compensate for abnormal genes or to make a beneficial protein. Gene therapy has a promising era in the field of dentistry. This review highlights various applications of gene therapy in dentistry, especially in areas such as salivary gland disorders, chronic pains, DNA vaccines, bone repair and implantology, head-and-neck cancer, orthodontic treatment, periodontal repair, and tooth regrowth.

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    Author(s) Name:

    Indhulekha Vimalakshan, Hansini B. Ajantha, M. P. Santhosh Kumar*

    Affiliation(s) Name:

    Department of Oral and Maxillofacial Surgery, Saveetha Dental College, Saveetha University, Chennai, Tamil Nadu, India

    *Corresponding author: Dr. M. P. Santhosh Kumar, Department of Oral and Maxillofacial Surgery, Saveetha Dental College and Hospital, Saveetha University, 162, Poonamallee High Road, Velappanchavadi, Chennai - 600 077, Tamil Nadu, India.

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    Indhulekha Vimalakshan, Hansini B. Ajantha, M. P. Santhosh Kumar*

    Title:Applications of gene therapy in dentistry - a review
    Journal:Drug Invention Today
    Vol(issue):10 (June)
    Page No: (969-975)
  • Experimental Methods Keywords

    Methodology:Bone formation, Clinical implications, Dentistry, Gene therapy, Gene transfer, Oral cancer, Pain, Salivary glands
    Research Materials:Gene therapy


Bone formation Clinical implications Dentistry Gene therapy Gene transfer Oral cancer Pain Salivary glands

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