Journal: JPR:BioMedRx:An International Journal

Article Id: JPRS-PP-0000233
Title: A study on drug-drug interactions in inpatients of general medicine department in a tertiary care teaching hospital
Category: Pharmacy Practice
Section: Research Article
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    Objective: Many studies have been done on drug interactions in their local hospitals. Drug interactions may lead to an increase or decrease in the beneficial or the adverse effects of the given drugs. We want to know the incidence rate of drug interactions in a tertiary care hospital in Chennai, our hospital setting, so that this data will be useful in creating awareness among the health care professionals. To study the incidence, frequency and severity of drug-drug interactions in patients admitted in General Medicine Department of Sri Ramachandra Hospital, and to create awareness among the health care professionals. Methods:  A prospective observational study was carried out in Inpatient department of General Medicine in a tertiary care teaching hospital. All inpatients of both sex and who were taking at least four or more drugs (polypharmacy) were included in the study. Over dosage cases were excluded from the study. The medications of the patients were analyzed for possible drug interactions by using computerized data base systems. Statistical analysis was done by Pearson correlation and nonparametric correlation to see the relationship between the number of drugs prescribed and the occurrence of pDDIs. Results and Discussion:  425 cases were analyzed. 342 prescriptions were with interactions. pDDIs were identified in about 80.5% of the study subjects. Of 1872 pDDIs, the major interactions were seen in 4.5%, moderate in 75.6% and minor in 19.9% of the patients. Among the DDIs, the majority were of pharmacodynamic (69.5%), followed by pharmacokinetic (23.4%) and unknown (7.1%). Statistical analysis by Pearson correlation and also by Nonparametric correlation (Kendall’s tau) showed that there was an extremely significant linear relationship (r = 0.623, r=0.496) (p<0.0001) between the number of drugs prescribed for a patient and the occurrence of pDDIs. Conclusion: This article will be useful in rationalizing the prescribing pattern by creating awareness among the physicians about the drug interactions. Detection and reporting of DDIs should be done by all health professionals to ensure patient’s safety. The pharmacist participation in the multidisciplinary team can improve the treatment to hospitalized patients and promote drug safety.

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    Author(s) Name:

    Kousalya Kaliamurthy*1, Sowmya Chirumamilla2, Manjunath Sundaresan3, Ramalakshmi Sankaralingam4, Saranya Punniyakotti4

    Affiliation(s) Name:

    *1Lecturer, Department of Pharmacy Practice, Faculty of Pharmacy, Sri Ramachandra University, Porur, Chennai – 600116
    2M.Pharm, Department of Pharmacy Practice, Faculty of Pharmacy, Sri Ramachandra University, Porur, Chennai – 600116
    3Professor and Head, Department of General Medicine, Sri Ramachandra University, Porur, Chennai – 600116
    4Lecturers, Department of Pharmacy Practice, Faculty of Pharmacy, Sri Ramachandra University, Porur, Chennai – 600116

    *Corresponding author.
    K.Kousalya
    Lecturer, Faculty of Pharmacy,
    Sri Ramachandra University,
    Chennai, Tamilnadu, India.


    Received on:16-10-2012; Revised on: 22-11-2012; Accepted on:27-12-2012

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    Author:

    Kousalya Kaliamurthy*1, Sowmya Chirumamilla2, Manjunath Sundaresan3, Ramalakshmi Sankaralingam4, Saranya Punniyakotti4

    Title: A study on drug-drug interactions in inpatients of general medicine department in a tertiary care teaching hospital
    Journal:JPR:BioMedRx:An International Journal
    Vol(issue):1 (January )
    Year:2013
    Page No: (11-14)
  • Experimental Methods Keywords

    Methodology:Pharmacokinetic, Pharmacodynamic
    Research Materials:drug

Keywords

Potential Drug-Drug Interactions (pDDIs) Severity Pharmacokinetic Pharmacodynamic

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