Journal: Drug Invention Today

Article Id: JPRS-Pcol-00002337
Title: Participation of catecholamines and corticosteroids in regulation of the autonomic tone in children
Category: Pharmacology
Section: Research Article
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    Aim: The article presents the results of the research of sympathetic-adrenal system and adrenal cortex (AC) functions, taking into account the features of heart rate vegetative regulation. Methods: They allowed to reveal a close contingency of excretion of catecholamines (CAs), metabolites of androgens and glucocorticoids, with the initial autonomic tone of children. It has been shown that children of both genders, with a predominance of sympathetic influences on cardiac rhythm, contrary to the normo- and vagotonics, had higher levels of norepinephrine (NE) excretion, combined with the increased secretion of 17-oxycorticosteroids (OCS) and 17-ketosteroids. 8–9-year-old girls are the exceptions. Results: They have relative decrease in activity of the glucocorticoid function of the AC in the sympathicotonia state. Furthermore, the boys - vagotonics, 11–12 years old, are the exceptions. Their intensity of the NE and 17-OCS excretion practically does not differ from that in the sympathotonics group. Conclusion: Thus, functional synergism of autonomic nervous system departments, coming out in the process of maintaining the autonomic balance, is accompanied by characteristic humoral-hormonal reactions of the organism in the form of simultaneous increase in levels of CAs and corticosteroids.

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    Author(s) Name:

    Maria V. Shaykhelislamova, Natalia B. Dikopolskaya*, Gulfia A. Bilalova, Anastasia V. Edranova, Julia D. Firsova

    Affiliation(s) Name:

    Department of Anatomy, Physiology and Human Health, Kazan (Privolzhsky) Federal University, 18, Kremlyovskaya Street, Kazan, 420008, Russia

    *Corresponding author: Natalia B. Dikopolskaya, Department of Anatomy, Physiology and Human Health, Kazan (Privolzhsky) Federal University, 18, Kremlyovskaya Street, Kazan, 420008, Russia

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    Author:

    Maria V. Shaykhelislamova, Natalia B. Dikopolskaya*, Gulfia A. Bilalova, Anastasia V. Edranova, Julia D. Firsova

    Title:Participation of catecholamines and corticosteroids in regulation of the autonomic tone in children
    Journal:Drug Invention Today
    Vol(issue):10 (July)
    Year:2018
    Page No: (1129-1133)
  • Experimental Methods Keywords

    Methodology:Catecholamines, Corticosteroids, Initial vegetative tone
    Research Materials: Boys and girls 7–12 years old

Keywords

Boys and girls 7–12 years old Catecholamines Corticosteroids Initial vegetative tone

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