Journal: Drug Invention Today

Article Id: JPRS-Pcol-00002343
Title: Water effect on the conformation of glycated albumin and blood viscosity in a diabetic patient
Category: Pharmacology
Section: Research Article
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    Introduction: Water can influence the conformation process of albumin and blood viscosity. The purpose of this study was to determine the effect of water molecules on the viscosity of plasma and plasma albumin conformation in diabetic patients. Methods: This study was using in silico molecular dynamics method. Molecular dynamics simulation program for a glycated albumin was run in various glucose concentrations (5 mg/ml, 11 mg/ml, and 20 mg/ml) and performed using YASARA software. Blood viscosity was measured using design methods with post-test only. The three steps measurement was including sampling, plasma collection, and blood viscosity measurement method. This study was obtained the concentration of glucose in the glycated albumin can affect the changes of conformational albumin and secondary structure of the protein albumin. Results: The results showed a decrease of plasma viscosity (PV) after addition of water. A decrease in PV showed that the water not only as a solvent but also related to the distribution of electrons contained in the molecule. Conclusion: Based on these results, it can be concluded that with the addition of water in the cell plasma may cause a decrease in viscosity. Moreover, the addition of plasma glucose concentrations can cause a conformational change in albumin.

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    Author(s) Name:

    Retnaningtyas Ekowati 1 *, Sutiman Bambang Sumitro2 , Djoko Wahono Soeatmadji 3

    Affiliation(s) Name:

    1 Health Polytechnic of Malang, Malang, East Java, Indonesia,

    2 Department of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University, Malang, East Java, Indonesia,

    3Department of Internal Diseases, Faculty of Medicine, Brawijaya University, Malang, East Java, Indonesia

    *Corresponding author: Dr. Retnaningtyas Ekowati, Health Polytechnic of Malang, Jalan Besar Ijen No 77C, Malang 65119, East Java, Indonesia.

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    Author:

    Retnaningtyas Ekowati 1 *, Sutiman Bambang Sumitro2 , Djoko Wahono Soeatmadji 3

    Title:Water effect on the conformation of glycated albumin and blood viscosity in a diabetic patient
    Journal:Drug Invention Today
    Vol(issue):10 (July)
    Year:2018
    Page No: (1156-1160)
  • Experimental Methods Keywords

    Methodology:Blood viscosity, Glycated albumin conformation, In silico, Water
    Research Materials:diabetic patient

Keywords

Blood viscosity Glycated albumin conformation In silico Water

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