Journal: JPR:BioMedRx:An International Journal

Article Id: JPRS-MD-0000235
Title: Potential bioactive compound from novel marine actinobacteria associated with antagonistic activity against human pathogens
Category: Marine Drug
Section: Research Article
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    A total of fifty six marine actinobacteria were isolated from the soil sediment of South Indian coastal region. The isolates were screened for invitro anti-microbial activity study. The anti-microbial screening showed that, three isolates (1, 2 and 18) exhibited potential activity against human pathogens such as Borrelia bargdosferi, Bartonella henselae, Listeria monocytogens, Helicobacter pylori and Camphylobacter jejuni by extracting bioactive compounds using ethyl acetate, acetone and dimethyl sulfoxide (DMSO). Among them, ethyl acetate extracted bioactive compounds from the isolate 1 exhibited virulent activity (18±0.67, 15±0.39, 11±0.75, 16±0.32 and 10±0.10) against all human pathogens than the other solvents and isolates. The partial characterization of the ethyl acetate extract (isolate - 1) by IR (Infra Red) spectra analysis revealed the possible presence of functional groups such as hydroxyl groups, unsaturated fatty acids and amine derivatives compounds in the extract. A unique 16S rRNA gene sequences and phylogenetic analysis provided strong evidence for the three novel actinobacterial strains (1, 2 and 18) namely Streptomyces acrimycini NGP (JX843532), Streptomyces albogriseolus NGP (JX843531), Streptomyces variabilis NGP (JX843530).

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    Author(s) Name:

    K. Selvam*, B.Vishnupriya, M.Yamuna, J. Tamil poonkuzhali and R.Ranjith kumar

    Affiliation(s) Name:

    Department of Biotechnology, Dr. N.G.P. Arts and Science College, Affiliated to Bharathiar University, Coimbatore - 48,Tamil Nadu, India

    *Corresponding author.
    K. Selvam
    Department of Biotechnology,
    Dr. N.G.P. Arts and Science College,
    Affiliated to Bharathiar University,
    Coimbatore - 48,Tamil Nadu, India


    Received on:16-08-2012; Revised on: 22-09-2012; Accepted on:28-12-2012

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    Author:

    K. Selvam*, B.Vishnupriya, M.Yamuna, J. Tamil poonkuzhali and R.Ranjith kumar

    Title:Potential bioactive compound from novel marine actinobacteria associated with antagonistic activity against human pathogens
    Journal:JPR:BioMedRx:An International Journal
    Vol(issue):1 (January )
    Year:2013
    Page No: (19-23)
  • Experimental Methods Keywords

    Methodology:antagonistic activity against human pathogens
    Research Materials:Actinobacteria

Keywords

Actinobacteria 16s rRNA anti-microbial activity phylogenetic analysis.

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