Journal: Drug Invention Today

Article Id: JPRS-Pcol-00002358
Title: Increased integrin and IKβ on the uterosacral ligament after childbirth
Category: Pharmacology
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    Background: Uterine prolapse is one manifestation of pelvic organs prolapse that characterized by the decline of the uterus from its original position as a result of the weakness of the pelvic floor buffer, especially sacrouterine and cardinal ligament. Objective: The objective of this study was to evaluate the level of integrin and IKβ expression on uterosacral ligament in women after vaginal delivery. Design: This was a cross-sectional study. Setting: Biomedical Laboratory. Patients and Methods: This research was conducted by collecting samples of biopsy uterosacral ligament from primigravida who underwent cesarean section after obstructive labor at Stage 1 and Stage 2 using consecutive sampling technique. Uterosacral ligaments of primigravida a term that has not entered labor phase and underwent elective cesarean section surgery were taken as control. Examination of Integrin and IKβ expression by immunohistochemistry. Main Outcome and Measures: Level of integrin and IKβ expression. Results: There were significant differences; mean of integrin activity in pregnant women has not been in labor group (92.8 ± 2.4%) compared to women in labor (95.99 ± 3.98%). There were significant differences between means of IKβ activity in pregnant group of women who never in labor (77.55 ± 6.77%) and group of pregnant women in labor (4:12 ± 93.59%). Conclusion: There were increased levels of integrin and IKβ in the uterosacral ligament of primigravida women in labor. There are increased levels of integrin and IKβ in the uterosacral ligament of primigravida women who underwent cesarean section due to obstructive labor at Stage 1 and Stage 2. Limitation: This study was not evaluated the level of nuclear factor kappa beta.

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    Author(s) Name:

    Rahajeng1,2
    *

    Affiliation(s) Name:

    1 Department of Obstetrics and Gynecology, Division of Urogynecology, Saiful Anwar Hospital of Malang, Jl. Jaksa Agung Suprapto 2A Malang, Indonesia,

    2 Medical Faculty, Brawijaya University, Malang, Indonesia

    *Corresponding author: Dr. Rahajeng, Department of Obstetrics and Gynecology, Division of Urogynecology, Saiful Anwar Hospital of Malang, Indonesia, Medical Faculty, Brawijaya University, Malang, Indonesia.

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    Author:

    Rahajeng1,2
    *

    Title:Increased integrin and IKβ on the uterosacral ligament after childbirth
    Journal:Drug Invention Today
    Vol(issue):10(7)
    Year:2018
    Page No: (1226-1230)
  • Experimental Methods Keywords

    Methodology:A cross-sectional study. Setting: Biomedical Laboratory
    Research Materials: Patients female

Keywords

IKβ Integrin MMP Primigravida

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