Journal: Drug Invention Today
Title: Docking study targeting 3CYY protein using Alzheimer drugs
Category: Drug (Discovery/Development)
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Abstract
Mirror neurons are the type of neurons that mimic the action of bystander. They are present in the premotor and primary motor cortex, rostral division of the ventral premotor cortex. They help in understanding, speech, social cognition, etc., Alzheimer disease is a neurodegenerative disorder which leads to loss of memory in elderly adults. It is caused mainly by two types of abnormalities such as beta-amyloid plaques and tau proteins. It is hypothesized to have a link with motor function and known as cognition hypothesis. In this study, Alzheimer drugs donepezil, rivastigmine, and memantine are chosen to estimate the binding efficiency using Autodock1.5.6 software which is a suite of automated docking tools. It is designed to predict how small molecules, such a substrate or drugs bind to receptor of known three-dimensional structure. From the result obtained we have concluded that Donepezil helps to treat Alzheimer more effectively than other drugs when it is combined with 3CYY protein.
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About the authors and Affiliations
Author(s) Name: A. Sarmila1 , S. Swetha1 , V. Meera1 , C. N. Hemalatha2 , M. Sekar Babu1 , M. Vijey Aanandhi 1 *
Affiliation(s) Name: 1 Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India,
2 Department of Pharmaceutical Chemistry, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India
*Corresponding author: Dr. M. Vijey Aanandhi, Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Pallavaram, Chennai, Tamil Nadu – 600 117, India.
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Author: A. Sarmila1 , S. Swetha1 , V. Meera1 , C. N. Hemalatha2 , M. Sekar Babu1 , M. Vijey Aanandhi 1 *
Title: Docking study targeting 3CYY protein using Alzheimer drugs Journal: Drug Invention Today Vol(issue): 10(7) Year: 2018 Page No: (1281-1284) -
Experimental Methods Keywords
Methodology: 3CYY protein, Alzheimer disease, AutoDock 1.5.6, Discovery studio visualizer 4.0, Mirror neurons Research Materials: Alzheimer drugs
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