Journal: JPR:BioMedRx:An International Journal

Article Id: JPRS-SDCS-0000242
Title: Design synthesis characterization and dual biological activity of some novel morphanthridine 6,11 dione derivatives
Category: Synthetic Drug Chemistry study
Section: Research Article
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    In modern medicinal chemistry, molecular modeling study is effectively participating in drug discovery process to reduce and the time and cost. The present study involved in the docking of 4-alkylamide/imides substituted 5H morphanthridine 6,11-dione [5H Dibenzo(b,e) apine 6,11-dione] derivatives 1(a-d), 2(a-d), 3(a-d) and 4(a-d) with Mono Amine Oxidase A protein to find out their potency of antidepressant activity. On the basis of docking result the molecules 1a, 2a, 2b, 2c, 3a, 3b, 4a and 4c were synthesized, characterized and evaluated for antidepressant activity by Forced Swim Test. Also all the 12 molecules synthesized characterized and evaluated to their in vitro anti bacterial activity by Agar Plate Disc diffusion method.

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    Author(s) Name:

    S.Sangamithirai* 1, N. Irfan 2

    Affiliation(s) Name:

    1Student of Pharmaceutical Chemistry, C.L.Baid Metha College of Pharmacy, Thorappakkam, Chennai-600097,Tamil Nadu, India.
    2Student of Pharmaceutical Chemistry, C.L.Baid Metha College of Pharmacy, Thorappakkam, Chennai-600097, Tamil Nadu, India.

    *Corresponding author.
    Sangamithirai.S
    Department of Pharmaceutical Chemistry,
    C L Baid Metha College of pharmacy,
    Thoraipakkam, Chennai-97,
    Tamil Nadu, India


    Received on:17-09-2012; Revised on: 19-10-2012; Accepted on:10-12-2012

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    Author:

    S.Sangamithirai* 1, N. Irfan 2

    Title:Design synthesis characterization and dual biological activity of some novel morphanthridine 6,11 dione derivatives
    Journal:JPR:BioMedRx:An International Journal
    Vol(issue):1 (January )
    Year:2013
    Page No: (68-73)
  • Experimental Methods Keywords

    Methodology:Design synthesis characterization
    Research Materials:novel morphanthridine 6,11 dione derivatives

Keywords

Molecular docking 5H Morphanthridine 6 11dione Alkyl arylamides/imides Antidepressant antibacterial.

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