Journal: Drug Invention Today

Article Id: JPRS-Pcol-00002432
Title: Comparison of antibacterial efficacy of three mouthwashes in chronic periodontitis patients - An in vitro study
Category: Pharmacology
Section: Research Article
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    Background: Dental plaque forms naturally on teeth and is of benefit to the host by helping to prevent colonization by exogenous species. The bacterial composition of plaque remains relatively stable despite regular exposure to minor environmental perturbations. This stability is due, in part, to a dynamic balance of both synergistic and antagonistic microbial interactions. However, homeostasis can break down, leading to shifts in the balance of the microflora, thereby predisposing sites to disease. This in vitro aims to evaluate the antimicrobial action of three mouthwashes with different active ingredients on dental plaque. Materials and Methods: The dental plaque and calculus were obtained from patients with simplified oral hygiene index score of >2. The calculus was crushed in thioglycolate broth and the resultant homogenate after centrifugation was incubated with three different mouthwashes, namely A - chlorhexidine (CHX), B - cetylpyridinium chloride (CPC), and C - essential oil (EO) mouthwashes. The samples were incubated in anaerobic jars (GASPAK) and the resultant colony-forming units were measured after 48 h. Results: The mean reduction of the anaerobic colony count of the sample treated with CHX was 24 and that of CPC was 9.8, whereas EO mouthwash was 143.8. Conclusion: This study concluded that significant reduction in colony-forming units was observed with CHX and CPC, and there was no significant decrease in the colony-forming units with EO mouthwashes.

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    Author(s) Name:

    Tandra Das1 , Asha Ramesh2 *, N. P. Muralidharan3

    Affiliation(s) Name:

    1 Department of Periodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India,

    2 Department of Periodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India,

    3 Department of Microbiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India

    *Corresponding author: Dr. Asha Ramesh, Department of Periodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University,Chennai - 600 077, Tamil Nadu, India.

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    Author:

    Tandra Das1 , Asha Ramesh2 *, N. P. Muralidharan3

    Title:Comparison of antibacterial efficacy of three mouthwashes in chronic periodontitis patients - An in vitro study
    Journal:Drug Invention Today
    Vol(issue):10 (August)
    Year:2018
    Page No: (1564-1568)
  • Experimental Methods Keywords

    Methodology:Antibacterial activity
    Research Materials:Cetylpyridinium chloride, Chlorhexidine, Essential oils

Keywords

Anaerobic culture Antibacterial Cetylpyridinium chloride Chlorhexidine Essential oils

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