Journal: Drug Invention Today

Article Id: JPRS-Pcol-00002434
Title: Clustered regularly interspaced short palindromic repeat technique in correcting sickle cell anemia – A review
Category: Pharmacology
Section: Research Article
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  • Abstract

    The human hemoglobin is made up of two alpha and two beta chains. In sickle cell anemia, the sixth position of the beta chain is affected, and glutamic acid is substituted for valine. Clustered regularly interspaced short palindromic repeat (CRISPR) can be used to edit the beta chain. This technique can be used to cut the DNA sequence at the desired location and thus is a very precise technique to correct the genetic disease.

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    Author(s) Name:

    Gayathri K. Rajpurohit, R. Gayathri*, V. Vishnu Priya

    Affiliation(s) Name:

    Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Science, Saveetha University, Chennai, Tamil Nadu, India

    *Corresponding author: Dr. R. Gayathri, Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Science, Saveetha University, 160, Poonamallee High Road, Chennai ‑ 600 077, Tamil Nadu, India.

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    Author:

    Gayathri K. Rajpurohit, R. Gayathri*, V. Vishnu Priya

    Title:Clustered regularly interspaced short palindromic repeat technique in correcting sickle cell anemia – A review
    Journal:Drug Invention Today
    Vol(issue):10 (August)
    Year:2018
    Page No: (1574-1577)
  • Experimental Methods Keywords

    Methodology:CRISPR, Hemoglobin, Mosaicism, Palindromic repeat
    Research Materials:Sickle cell anemia

Keywords

CRISPR Hemoglobin Mosaicism Palindromic repeat Sickle cell anemia

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