Journal: JPR:BioMedRx:An International Journal

Article Id: JPRS-SDCS-0000244
Title: Benzimidazole chalcones: Potent glycosidase inhibitors
Category: Synthetic Drug Chemistry study
Section: Research Article
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    Benzimidazole-2-substituted chalcones, a new class of glycosidase inhibitors are synthesized using recyclable PEG-400 as an alternative reaction solvent. Effect of synthesized compounds on glycosidase enzymes (α-amylase and glucoamylase) were studied in vitro. Chalcones bearing electron withdrawing groups exhibit strong α-glycosidase inhibitory action whereas electron donating groups displayed moderate inhibitory action. However, nitro derivative of chalcones 3d (IC50 = 1 mM), 3m (IC50 = 2 mM) and 3n (IC50 = 4.9 mM) proved to be potent inhibitors against a-amylase whereas derivative 3h (IC50 = 19 mM) was found to be moderate inhibitor of glucoamylase.

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    Author(s) Name:

    Gangadhar A. Meshram,* Vipul A. Vala, Ganesh S. Metangale, Shruti S. Deshpande, Shraddha S. Khamkar, Pramod A. Wagh

    Affiliation(s) Name:

    Department of Chemistry, University of Mumbai, Vidyanagari, Kalina, Santacruz (E), Mumbai- 400 098, India

     

    *Corresponding author.
    Dr. Gangadhar A. Meshram
    Department of Chemistry, University
    of Mumbai, Vidyanagari, Kalina,
    Santacruz (E), Mumbai- 400 098, India


    Received on:17-09-2012; Revised on: 19-10-2012; Accepted on:10-12-2012

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    Author:

    Gangadhar A. Meshram,* Vipul A. Vala, Ganesh S. Metangale, Shruti S. Deshpande, Shraddha S. Khamkar, Pramod A. Wagh

    Title:Benzimidazole chalcones: Potent glycosidase inhibitors
    Journal:JPR:BioMedRx:An International Journal
    Vol(issue):1 (January )
    Year:2013
    Page No: (78-81)
  • Experimental Methods Keywords

    Methodology:Assay of a-amylase,Assay of glucoamylase
    Research Materials:Benzimidazole chalcones

Keywords

α-glycosidase inhibitors Benzimidazole chalcones PEG-400 postprandial hyperglycemia.

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