Journal: Journal of Pharmacy Research

Article Id: JPRS-PS-00002442
Title: Developing the formula of a potential medicinal agent for treating candidiasis
Category: Pharmaceutical Sciences
Section: Research Article
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    Background: Infections caused by fungi of the genus Candida are certainly actual and growing problem for modern medicine. At present, there has been a substantial increase in cases of candidiasis, which most authors associate with the adverse effects of the external environment on the human body, the expansion of health technologies, the use of new therapeutic approaches, the high rate of the development of immunodeficiency, both habitual and acquired, as well as with an undue drug administration that reduce immunity, including broad-spectrum antibiotics. According to WHO, there is an increase in the incidence of mycoses, among which candidiasis is the leading cause. In more than 75% of cases in the treatment of patients, administration of the antibiotics has been deemed to be unsound. Aim and objective: The aim of our study was to develop the original antimicrobial and antifungal agents of the different nature, with new properties and another mechanism of action, which today is the most promising area. The paper addresses the issue of developing similar preparation containing herbal medicines with antimicrobial, antifungal, immunomodulating, keratolytic and immunogenic properties in a combination with a synthetic antimycotic of the non-antibiotic nature. Materials and methods: As an opportunity, there should be considered pharmaceutical preparation containing in the complex not bacterial antimycotics, but substances having a specific keratolytic effect, some of organic acids, herbal medicines with antimicrobial, antifungal, immunomodulating and immunogenic properties. Result and conclusion: There has been developed the formula of a new type of cream for the treatment of candidiasis. It contains therapeutic plant substances in combination with non-antibiotic synthetic substances. The cream’s formula was prepared on a highly-adsorptive base that we developed. The results of their primary study allow us for considering them as potential antimicrobial remedies for the local treatment of candidiasis.

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    Author(s) Name:

    Abuladze Nino Bejhan1 *, Chubinidze Natia Zauri 2 , Iavich Pavel Abram2

    Affiliation(s) Name:

    1 Department of Pharmacy, Akaki Tsereteli State University, Kutaisi 4600, Georgia,

    2 Department of Stomatology and Pharmacy, Akaki Tsereteli State University, Kutaisi 4600, Georgia

    *Corresponding author: Abuladze Nino Bejhan, Department of Pharmacy, Akaki Tsereteli State University, Tamar Mepe 59. Kutaisi 4600, Georgia

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    Author:

    Abuladze Nino Bejhan1 *, Chubinidze Natia Zauri 2 , Iavich Pavel Abram2

    Title:Developing the formula of a potential medicinal agent for treating candidiasis
    Journal:Journal of Pharmacy Research
    Vol(issue):12 (June)
    Year:2018
    Page No: (866-870)
  • Experimental Methods Keywords

    Methodology: antimicrobial, antifungal, immunomodulating and immunogenic properties
    Research Materials:plant-based antimycotics, synthetic non-antibiotic antimycotics

Keywords

Candidiasis cream plant-based antimycotics synthetic non-antibiotic antimycotics

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