Journal: Drug Invention Today

Article Id: JPRS-D(DD)-00002448
Title: Study the effect of wet granulation and fusion methods on preparation, characterization, and release of lornoxicam sachet effervescent granules
Category: Drug (Discovery/Development)
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  • Abstract

    The present work is based on the formulation of effervescent granules of lornoxicam unit dose. Six such formulations were prepared using citric and tartaric acids and sodium bicarbonate as effervescent base at different ratios. Mannitol and aspartame were used as sweetening agents since lornoxicam has a bitter taste. The granules were prepared by the wet and fusion method, and they were evaluated for flow property (such as angle of repose, bulk density, tapped density, and Carr’s index), particle size, pH, effervescence time, in vitro dissolution studies, and drug content. The formulated effervescent granules exhibited excellent flow properties and bulk density suitable for a unit dose. All the formulations exhibited effervescence time <60 s and dissolution profile was found to be >75% in 5 min. F2 formulation was selected as the best formulation because of their physicochemical characteristics; it is concluded that the wet method resulted in better granules compared to fusion method.

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    Author(s) Name:

    Zainab Eassa Jassim*, Nawal A. Rajab, Nada H. Mohammed

    Affiliation(s) Name:

    Department of Pharmaceutics, College of Pharmacy, University of Baghdad, Baghdad, Iraq

    *Corresponding author: Zainab Eassa Jassim, Department of Pharmaceutics, College of Pharmacy, University of Baghdad, Iraq

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    Author:

    Zainab Eassa Jassim*, Nawal A. Rajab, Nada H. Mohammed

    Title:Study the effect of wet granulation and fusion methods on preparation, characterization, and release of lornoxicam sachet effervescent granules
    Journal:Drug Invention Today
    Vol(issue):10(9)
    Year:2018
    Page No: (1612-1616)
  • Experimental Methods Keywords

    Methodology:Effervescent granules,Preparation methods
    Research Materials:, Lornoxicam

Keywords

Effervescent granules Lornoxicam Preparation methods

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