Journal: Drug Invention Today

Article Id: JPRS-Pcol-00002467
Title: Therapeutic effects of L-arginine on aluminum chloride- induced dementia of Alzheimer’s type in mice
Category: Pharmacology
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    Objective: The present study was aimed to evaluate the protective effect of amino acid L-Arginine on aluminum chloride (AlCl 3 )-induced neurological and pathological changes in dementia of Alzheimer’s type in mice (50 mg/kg) for 60 days. Method: The selected aminoacid L-Arginine is administrated along with AlCl 3 as injection for a period of 60 days. The study showed that aluminum exposure significantly causes the learning and memory impairment in Morris water maze test. Administration of L-Arginine significantly reverts glial scarring and edema in the mice brain. Histopathology: The histopathological studies in the hippocampus of mice brain also supported that L-Arginine (250 mg/kg, p.o.,) and L-Arginine (500 mg/kg, p.o.,) which reduces the toxicity of AlCl 3 and secure the normal histoarchitecture pattern of the hippocampus part of the brain. Results and Conclusion: The behavioral impairment caused by aluminum was significantly attenuated by L-Arginine.

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    Author(s) Name:

    S. P. Ajith Kumar1 , D. Kumaresan1 , S. Nithya1 *, P. Muralidharan2

    Affiliation(s) Name:

    1Assistant Professor, Department of Pharmacology, School of Pharmaceutical Sciences, Vels Institute of Science Technology and Advanced Studies, Pallavaram, Chennai, Tamil Nadu, India,

    2 Professor and Head, Department of Pharmacology, CL Baid Mehta College of Pharmacy, Thoraipakkam, Chennai, Tamil Nadu, India

    *Corresponding author: S. Nithya, Department of Pharmacology, School of Pharmaceutical Sciences, Vels Institute of Science Technology and Advanced Studies, Pallavaram, Chennai, Tamil Nadu, India.

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    Author:

    S. P. Ajith Kumar1 , D. Kumaresan1 , S. Nithya1 *, P. Muralidharan2

    Title:Therapeutic effects of L-arginine on aluminum chloride- induced dementia of Alzheimer’s type in mice
    Journal:Drug Invention Today
    Vol(issue):10(9)
    Year:2018
    Page No: (1708-1711)
  • Experimental Methods Keywords

    Methodology:Therapeutic effects,Dementia, Histopathology studies
    Research Materials: L-Arginine,

Keywords

Aluminium chloride Dementia Histopathology studies L-Arginine Memory impairment Protective effect

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