Journal: JPR:BioMedRx:An International Journal

Article Id: JPRS-DTBA-0000248
Title: Chitosan-Alginate Drug Loaded Polymer Network for Accelerated Wound Healing
Category: Drug release and biodegrading ability
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  • Abstract

    The biodegradable sponge composed of chitosan and sodium alginate at different ratio (1:3, 2:2, 3:1) was prepared and analyzed for their swelling, in vitro drug release and biodegrading ability. Plumbagin a multifunctional agent was incorporated into chitosan and alginate sponge to deter wound infection. The water uptake ability, lysozyme degradation resistance and persistence drug release was found to be more appropriate in the sponge prepared with high ratio of chitosan to alginate. An in vivo animal test employed confirms the applicability of the sponge as a wound dressing material without any adverse symptoms. The sponge had better wound healing effect than cotton gauze and by incorporating plumbagin a more accelerated wound healing was observed in animal model.

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    Author(s) Name:

    Venkatrajah Balasubramanian *1, Vanitha Malathy V2, Elayarajah Balasubramanian1, Anju Joseph1, R. Girija1,

    Affiliation(s) Name:

    1Department of Microbiology & Bioinformatics, CMS College of Science & Commerce, Coimbatore, Tamil Nadu, India.
    2Department of Zoology, Kunthavai Naachiar Government Arts College for Women, Tanjore, Tamil Nadu, India.

    *Corresponding author.
    Venkatrajah Balasubramanian,
    Assistant Professor,
    Department of Microbiology & Bioinformatics,
    CMS College of Science & Commerce,
    Coimbatore, Tamil Nadu, India.


    Received on:28-10-2012; Revised on: 23-11-2012; Accepted on:16-12-2012

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    Author:

    Venkatrajah Balasubramanian *1, Vanitha Malathy V2, Elayarajah Balasubramanian1, Anju Joseph1, R. Girija1,

    Title:Chitosan-Alginate Drug Loaded Polymer Network for Accelerated Wound Healing
    Journal:JPR:BioMedRx:An International Journal
    Vol(issue):1 (January )
    Year:2013
    Page No: (97-101)
  • Experimental Methods Keywords

    Methodology:wound dressing, wound healing
    Research Materials:Plumbagin

Keywords

Plumbagin chitosan alginate biodegradable sponge wound dressing wound healing

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