Journal: Drug Invention Today

Article Id: JPRS-Pcol-00002480
Title: Quantitative assessment of antioxidants and oxidative stress against tooth paste and metal-induced toxicity
Category: Pharmacology
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    Aim: The aim of this study is to quantitatively evaluate oxidative stress against tooth paste and metal-induced toxicity. Introduction: Exposure to heavy metals is a common phenomenon due to their environmental pervasiveness. Metal intoxication particularly neurotoxicity, genotoxicity, or carcinogenicity is widely known. The unifying factor in determining toxicity and carcinogenicity for all these metals is the generation of reactive oxygen and nitrogen species. The toxic manifestations of these metals are caused primarily due to an imbalance between pro-oxidant and antioxidant homeostasis which is termed as oxidative stress. Materials and Methods: Five criteria such as estimation of lipid peroxidase, myeloperoxidase, protein carbonyl content, superoxide dismutase, and catalase ,were taken for evaluating the oxidative stress and antioxidants levels in tooth paste. Result: Thus, this study shows that there is a decrease in antioxidants levels and subsequent increase in oxidative stress levels in heavy metal tooth paste. Conclusion: In the present study, a decrease in antioxidants in heavy metal containing toothpastes shows that it can lead to localized disorder as well as systemic disorders such as cancer and cardiovascular diseases. Hence, toothpaste containing heavy metals should be avoided.

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    Author(s) Name:

    Preetha Parthasarathy1 , V. Vishnu Priya2 *, R. Gayathri 2

    Affiliation(s) Name:

    1Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India,

    2Department of Biochemistry, Saveetha Dental College, Saveetha Institute of
    Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India

    *Corresponding author: V. Vishnu Priya, Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.

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    Author:

    Preetha Parthasarathy1 , V. Vishnu Priya2 *, R. Gayathri 2

    Title:Quantitative assessment of antioxidants and oxidative stress against tooth paste and metal-induced toxicity
    Journal:Drug Invention Today
    Vol(issue):10(9)
    Year:2018
    Page No: (1749-1753)
  • Experimental Methods Keywords

    Methodology:Antioxidants, Free radicals, Oxidative stress, Reactive oxygen species
    Research Materials:Saliva

Keywords

Antioxidants Free radicals Oxidative stress Reactive oxygen species Saliva

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