Journal: Drug Invention Today

Article Id: JPRS-Pcol-00002506
Title: Analysis of pH and variation in buffering capacity of saliva in normal and patients with carcinoma of buccal mucosa - A pilot study
Category: Pharmacology
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    Aim: The aim of the study is to analyze the pH and variation in buffering capacity of saliva in normal and patients with carcinoma of buccal mucosa. Materials and Methods: The study was conducted in the outpatient department of Saveetha Dental College, Chennai. Histopathologically diagnosed cancer patients were included in the study. The pH of salivary samples of both the control and tests was noted before and after the addition of mild acid. The data collected were analyzed statistically. Results: The study reveals that the mean difference in pH before and after adding the mild acid tends to be greater in case of cancer patients when compared to healthy individuals, thus suggesting that there is a noticeable decrease in the buffering capacity of the saliva samples collected from patients suffering from oral cancer. Conclusion: Saliva has the potential to become a first-line diagnostic aid of choice owing to the advancements in detection technologies in the past one decade. Therefore, these parameters can be areas of further research with an increased sample size, which, in turn, may help in throwing some light on the newer non-invasive prognostic markers for diagnosis of cancer.

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    Author(s) Name:

    R. J. Ilankizhai 1 , V. Vishnu Priya2 *, R. Gayathri 2

    Affiliation(s) Name:

    1 Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India,

    2 Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India

    *Corresponding author: V. Vishnu Priya, Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India

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    Author:

    R. J. Ilankizhai 1 , V. Vishnu Priya2 *, R. Gayathri 2

    Title:Analysis of pH and variation in buffering capacity of saliva in normal and patients with carcinoma of buccal mucosa - A pilot study
    Journal:Drug Invention Today
    Vol(issue):10 (September )
    Year:2018
    Page No: (1856-1859)
  • Experimental Methods Keywords

    Methodology:Oral cancer,Prognostic markers, Radiation therapy
    Research Materials:Saliva in normal and patients with carcinoma

Keywords

Buffering capacity Oral cancer Prognostic markers Radiation therapy Saliva

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