Journal: JPR:BioMedRx:An International Journal

Article Id: JPRS-PDRS-0000253
Title: Anxiolytic and antidepressant activity of Barleria buxifolia Linn
Category: Plant Drugs Related Study
Section: Research Article
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    Anxiety and Depression are overwhelming mood disorders which account for 15% of the world population.With the drawback of existing treatment the researchers has focused on plant extracts which are having no side effects.Barleria buxifolia (From the family Acanthaceae) is traditionally used in bronchitis and inflammation.The aim of the present study was to investigate the anxiolytic and andepressant activities.An aqueous extract of dried leaves of Barleria buxifolia(AqEOBB) was prepared.The anxiolytic and antidepressant of this aqueous extract has been evaluated by Elevated Plus Maze[EPM] model and Forced Swim Test[FST].The aqueous extract of Barleria buxifolia has shown effect in dose dependent manner.In EPM model the dose of 200mg/kg has shown significant [p<0.01] effect by increasing the number of entries and time spent in open arms when compared to control group indicating anxiolytic activity and in FST by decreasing the duration of immobity.Barleria buxifolia could be the alternative in treatment but further studies are required to evaluate the mechanism by which the anxiolytic and anti-depression activities are shown.

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    Author(s) Name:

    A.Purna chander, M.Nishitha, B.Shravanthi, Y.Haritha Sri, M.Kishore kumar, MD.Baheerudddin

    Affiliation(s) Name:

    Department of Pharmacology,Vishnu Institute of Pharmaceutical Education and Research Vishnupur,Narsapur,Medak -502313

    *Corresponding author.
    A.Purna chander,
    Assistant professor,
    Department of Pharmacology,
    Vishnu institute of pharmaceutical education and Research,
    Narsapur,Medak


    Received on:05-11-2012; Revised on: 09-12-2012; Accepted on:19-01-2013

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    Author:

    A.Purna chander, M.Nishitha, B.Shravanthi, Y.Haritha Sri, M.Kishore kumar, MD.Baheerudddin

    Title:Anxiolytic and antidepressant activity of Barleria buxifolia Linn
    Journal:JPR:BioMedRx:An International Journal
    Vol(issue):1 (February)
    Year:2013
    Page No: (122-124)
  • Experimental Methods Keywords

    Methodology:Elevated Pus Maze,Forced Swim Test.
    Research Materials:Barleria buxifolia

Keywords

Barleria buxifolia Elevated Pus Maze Forced Swim Test.

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