Journal: Drug Invention Today

Article Id: JPRS-Pcol-00002547
Title: Role of monoclonal antibodies in immune tolerance posttransplantation: An update
Category: Pharmacology
Section: Research Article
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    Aim: This study aims to review about the role of monoclonal antibodies in immune tolerance posttransplantation. Objective: The objective of this study was to review the database for literature collection related to organ transplantation and graft rejection reactions and role of monoclonal antibodies in providing immune tolerance to such patients. Background: Antibody derived from a unique parent cell and has identical immune cells that are clones and specific for a single epitope is monoclonal antibody. For most research and therapeutic purpose, a monoclonal antibody is needed. Monoclonal antibody production was first introduced by Kolher and Milstein, in 1975. CD20 monoclonal antibody, anti-B monoclonal antibody, and monoclonal antibody OKT3 are some of the antibodies used in transplantation. Reason: Immunosuppressive drugs are taken lifelong after transplantation. Drugs such as cyclosporine and azathioprine are taken for immune tolerance. Monoclonal antibodies are also taken to provide good immune tolerance post-renal, hepatic, and heart transplantation. Conclusion: The article highlights the monoclonal antibodies such as CD4, CD8, interleukin-2 human monoclonal antibodies, and regulatory T-cell antibodies and their role in immune tolerance posttransplantation.

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    Author(s) Name:

    T. Santhosh1 , Shreesha2 , V. Rakshagan3 , Ashish R. Jain3 *

    Affiliation(s) Name:

    1 Department of Prosthodontics, Saveetha Dental College and Hospitals, Saveetha University, Chennai, Tamil Nadu, India,

    2 Department of Biochemistry, Saveetha Dental College, Saveetha University, Chennai, Tamil Nadu, India,

    3 Department of Prosthodontics, Saveetha Dental College and Hospitals, Saveetha University, Chennai, Tamil Nadu, India

    *Corresponding author: Dr. Ashish R. Jain, Department of Prosthodontics, Saveetha Dental College and Hospital, Saveetha University, Ponamalle High Road, Chennai - 600 127, Tamil Nadu, India.

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    Author:

    T. Santhosh1 , Shreesha2 , V. Rakshagan3 , Ashish R. Jain3 *

    Title:Role of monoclonal antibodies in immune tolerance posttransplantation: An update
    Journal:Drug Invention Today
    Vol(issue):10 (Oct)
    Year:2018
    Page No: (2017-2019)
  • Experimental Methods Keywords

    Methodology:An update
    Research Materials: Anti-B monoclonal antibody

Keywords

Anti-B monoclonal antibody Immune tolerance Monoclonal antibodies Transplantation

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