Journal: JPR:BioMedRx:An International Journal

Article Id: JPRS-PDRS-0000255
Title: Analgesic, anti-inflammatory and anti-arthritic activity of Euphorbia thymifolia Linn phytosterol fraction
Category: Plant Drugs Related Study
Section: Research Article
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    Euphorbia thymifolia Linn. (family Euphorbiaceae) is an annual herb belonging to genus Euphorbia having many medicinal uses. The present study was carried out to evaluate the analgesic, anti-inflammatory and anti-arthritic activity of the phytosterol fraction of E. thymifolia (ETTS). Phytosterol was separated from the petroleum ether extract of dried aerial part, by refluxing with 5% alcoholic KOH for 4 hr followed by filtration. LD50 was calculated as 283 mg kg-1, i.p and a dose level of 20, 30 and 40 mg kg-1 was chosen for in vivo studies. Analgesic activity was evaluated in mice using morphine and naloxone on Hot Plate instrument to assess the involvement of opioid receptor in analgesic activity. Anti-inflammatory and anti-arthritic activity was evaluated against carrageenan induced paw edema and Complete Freund’s Adjuvant induced arthritis in rats by estimating TNF-a and knee joint Histopathology. ETTS showed significant (P < 0.01) increase in hot plate reaction time which was reversed in presence of naloxone. ETTS at 40 mg kg-1 decreased (P < 0.01-0.001) paw volume, arthritic index and TNF-a expression. ETTS showed repair of articular surfaces with small areas of erosion and irregularities with invasion of connective tissue. E. thymifolia total sterol possesses moderate analgesic, and potent anti-inflammatory and anti-arthritic activities at 40 mg kg-1. Centrally acting mechanism may be involved in analgesic response modulating the opioid receptors having morphine like action as the effects of ETTS was blocked by naloxone. ETTS led to marked repair of articular surfaces and reduction of tissue edema and cellular infiltration.

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  • About the authors and Affiliations

    Author(s) Name:

    P. Bigoniya*, A. Singh Thakur, S. Singh

    Affiliation(s) Name:

    Department of Pharmacology and Pharmacognosy, Radharaman College of Pharmacy, Bhadbhada Road, Ratibad, Bhopal, India.

    *Corresponding author.
    Dr. Papiya Bigoniya
    Principal, Radharaman College of Pharmacy, Fatehpur Dobra, Bhadbhada Road, Ratibad, Bhopal-462 002, M.P., India. 


    Received on:19-11-2012; Revised on: 26-12-2012; Accepted on:28-01-2013

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    Author:

    P. Bigoniya*, A. Singh Thakur, S. Singh

    Title:Analgesic, anti-inflammatory and anti-arthritic activity of Euphorbia thymifolia Linn phytosterol fraction
    Journal:JPR:BioMedRx:An International Journal
    Vol(issue):1 (February)
    Year:2013
    Page No: (130-134)
  • Experimental Methods Keywords

    Methodology:Analgesic, Anti-inflammatory, Anti-arthritic,
    Research Materials:E. thymifollia

Keywords

E. thymifollia Analgesic Anti-inflammatory Anti-arthritic Phytosterol TNF-α.

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