Journal: JPR:BioMedRx:An International Journal

Article Id: JPRS-Pha-0000256
Title: Evaluation of anticonvulsant activity of ethanolic extract of Nymphaea alba Linn. (white water lily) and its comparison with phenytoin sodium and sodium valproate in albino rats
Category: Pharmacology
Section: Research Article
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    Objective: The aim of the present work was to evaluate the anticonvulsant activity of ethanolic extract of Nymphaea alba Linn. in rats. Materials and methods: Anticonvulsant activity of ethanolic extract of Nymphaea alba Linn.(200 and 100mg/kg oral) is evaluated in albino rats both in MES induced artificial seizures by Electroconvulsiometer and Pentylene tetrazole (70mg/kg i.p)induced seizures. Phenytoin sodium and sodium valproate were used as standard drugs for these two methods respectively. All drugs were administered orally one hour before tests. Results: Oral administration of ethanolic extract of Nymphaea alba (200 and 100mg/kg) 1 hour before artificial induction of seizures significantly prevented Tonic hind limb extension (THLE) and also decreased the duration of seizures in MES models and was comparable to phenytoin sodium. In PTZ induced models it showed some protection compared to control but was statistically not significant. Conclusion: Nymphaea alba has significant anticonvulsant property in MES model at the dose of 100 and 200mg/kg and is comparable to phenytoin sodium. But Nymphaea alba did not show statistically significant anticonvulsant property in PTZ induced seizures.

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    Author(s) Name:

    Dr. Shankar A. S1, Dr. Suneel kumar reddy2, Dr. Raghuprasada M. S. 1, Dr. Ramachandra K. 1, Dr. Keerthi Sagar J. 1, Dr. Reshma S. R. 1

    Affiliation(s) Name:

    1Postgraduate student, Department of Pharmacology. JJM Medical College, Davanagere, Karnataka, India.
    2Assistant Professor, Department of Pharmacology. JJM Medical College, Davanagere, Karnataka, India.

    *Corresponding author.
    Dr. Shankar A. S.
    Postgraduate student,
    Department of Pharmacology,
    JJM Medical College,
    Davanagere-577004,
    Karnataka ,India


    Received on:17-10-2012; Revised on: 19-11-2012; Accepted on:10-01-2013

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    Author:

    Dr. Shankar A. S1, Dr. Suneel kumar reddy2, Dr. Raghuprasada M. S. 1, Dr. Ramachandra K. 1, Dr. Keerthi Sagar J. 1, Dr. Reshma S. R. 1

    Title: Evaluation of anticonvulsant activity of ethanolic extract of Nymphaea alba Linn. (white water lily) and its comparison with phenytoin sodium and sodium valproate in albino rats
    Journal:JPR:BioMedRx:An International Journal
    Vol(issue):1 (February)
    Year:2013
    Page No: (135-139)
  • Experimental Methods Keywords

    Methodology:Anticonvulsant activity
    Research Materials:Nymphaea alba

Keywords

Epilepsy Nymphaea alba protective Electroconvulsiometer and Pentylene tetrazole.

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