Journal: JPR:BioMedRx:An International Journal

Article Id: JPRS-PDRS-0000259
Title: Phytochemical Screening and Central Nervous System Activity of Methanolic Extract of Cucumis sativus Leaves.
Category: Plant Drugs Related Study
Section: Research Article
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    Bioactive plant parts remain popular as therapeutics in all age. Their significance is intensifying day by day to provide safe, affordable and obtainable drugs for all classes of people. The present investigation was designed to evaluate the activity of Cucumis sativus leaves as analgesic and CNS depressant in model mice along with phytochemical screening. The analgesic activity of the extract was examined using acetic acid-induced writhing test (chemically induced pain) and tail immersion test (thermally induced pain) at the dose of 200 and 300 mg/kg body weight. CNS depressant activity was evaluated by pentobarbitone-induced hypnosis, neuropharmacological experiment by open field and hole cross tests at the doses of 200 and 400 mg/kg body weight. The results of the statistical analysis showed that the plant extract had significant (P<0.001) dose dependent CNS depressant and antinociceptive activities. The extract, at the dose of 300mg/kg showed better analgesic effects in tail immersion test, indicating its centrally acting analgesic property and exerted 63.64% inhibition of writhing response in the acetic acid-induced writhing model, which is very close to the reference drug Indomethacin (65.91%). The extract also produced a dose-dependent reduction of the onset and duration of pentobarbitone-induced hypnosis, reduction of locomotor and exploratory activities in the open field, hole cross tests. This analgesic and CNS-depressant activity of the extract might be because of presence of different chemical compounds in it. Altogether, these results suggest that the leaves extract of Cucumis sativus possesses remarkable CNS depressant and analgesic properties.

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    Author(s) Name:

    F. Nasrin1*, S. Ahmad2, M.T. Hossen1, Kamrunnahar3

    Affiliation(s) Name:

    1Department of Pharmacy, Southeast University, Banani, Dhaka-1213, Bangladesh.
    2 Department of Electrical & Electronics Engineering, BUET, Dhaka-1000, Bangladesh.
    3Department of Pharmacy, State University of Bangladesh, Dhaka, Bangladesh.

    *Corresponding author.
    Fatema Nasrin
    Lecturer
    Department of Pharmacy,
    Southeast University
    Banani, Dhaka-1213, Bangladesh.


    Received on:19-12-2012; Revised on: 26-12-2012; Accepted on:04-02-2013

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    Author:

    F. Nasrin1*, S. Ahmad2, M.T. Hossen1, Kamrunnahar3

    Title:Phytochemical Screening and Central Nervous System Activity of Methanolic Extract of Cucumis sativus Leaves.
    Journal:JPR:BioMedRx:An International Journal
    Vol(issue):1 (February)
    Year:2013
    Page No: (143-148)
  • Experimental Methods Keywords

    Methodology:acetic acid-induced writhing test (chemically induced pain) and tail immersion test (thermally induced pain)
    Research Materials:Cucumis sativus Leaves.

Keywords

CNS-depressant pentobarbitone Antinociceptive Centrally acting analgesic Writhing Locomotor activity.

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