Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-000026
Title: Design and in vitro evaluation of alginate beads of ambroxol hydrochloride
Category: Pharmaceutics
Section: Research Article
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  • Abstract

    Oral slow and sustained release drug delivery system can release their drug content with a controlled manner, producing a desirable blood serum level, reduction in drug toxicity and improving the patient compliance by prolonging dosing intervals. The major drawback of orally administered drug like ambroxol as mucolytic agent in a variety of respiratory disorders has a shorter biological half-life. To overcome these drawbacks, an attempt has been made to develop a sustained release dosage form of ambroxol embedded alginate microbeads prepared by ionotropic gelation technique. The beads were characterized for its particle size, drug content and in vitro release studies. The results revealed that the surface adhering drug was found to release immediately and a steady state of release was obtained up to 12 h from all the batches. The results indicated there was an inverse relationship between the concentration of alginate and drug release. The drug release was found to follow non-fickian diffusion obeying first order kinetics.

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    Author(s) Name:

    D. Nagasamy Venkatesh*1, N. Ramesh1, S. Karthick1, K. Mohammed Fakrudeen1, B. Uthayakumar1, R. M. Valliappan1, S. Vinu Deepak1, Biplab Debnath1, M. K. Samanta1 and B. Suresh1

    Affiliation(s) Name:

    1Department of Pharmaceutics, JSS College of Pharmacy, Ooty-643001.Tamil Nadu.

    For correspondence:

    D.Nagasamy Venkatesh,

    Department of Pharmaceutics, JSS College of Pharmacy, Ooty- 643001.Tamil Nadu, India.


    E-mail:1.nagasamyvenkatesh@rediffmail.com


    Received on:17-08-2008; Accepted on :02-10-2008

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    Author:

    D. Nagasamy Venkatesh*1, N. Ramesh1, S. Karthick1, K. Mohammed Fakrudeen1, B. Uthayakumar1, R. M. Valliappan1, S. Vinu Deepak1, Biplab Debnath1, M. K. Samanta1 and B. Suresh1

    Title:Design and in vitro evaluation of alginate beads of ambroxol hydrochloride
    Journal:Journal of Pharmacy Research
    Vol(issue):1 (Oct-December 2008)
    Year:2008
    Page No: (139-142)
  • Experimental Methods Keywords

    Methodology:Design and in vitro evaluation
    Research Materials:alginate beads of ambroxol hydrochloride

Keywords

Sodium alginate ambroxol microbeads ionotropic gelation technique and peppa’s model

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