Journal: JPR:BioMedRx:An International Journal

Article Id: JPRS-Ph-0000262
Title: Solubility enhancement and formulation of rapid disintegrating tablet of Febuxostat Cyclodextrin complex.
Category: Pharmaceutics
Section: Research Article
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    Febuxostat is a non-purine, xanthine oxidase inhibitor. It is a BCS class II drug. It exhibits poor bioavailability of about 49% which is attributed to its poor solubility. The present work was aimed at overcoming these two limitations. Drug-β-cyclodextrin and Hydroxy propyl â-cyclodextrin complex were prepared and characterized by FTIR, DSC and PXRD studies. Saturation solubility study was carried out to evaluate the increase in the solubility of febuxostat. In vitro studies showed that the solubility and dissolution rate of febuxostat were significantly improved by complexation with β-cyclodextrin and Hydroxy propyl β-cyclodextrin with respect to drug alone. The inclusion complexes with β-CD prepared by spray drying method showed highest solubility (305.09%) and fast dissolution profile while inclusion complexes with HP-β-CD prepared by co-evaporation method showed highest solubility (330.24%) and it was incorporated into rapid disintegrating tablet. The tablets were prepared by using three different superdisintegrants, crosspovidone, sodium starch glycolate and croscarmellose sodium by direct compression. Tablets were evaluated for the hardness, friability, assay, thickness, disintegration time and average weight. Tablets shows enhance dissolution rate as compared to pure febuxostat.

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    Author(s) Name:

    Bhanudas S. Kuchekar1, Varsha B. Divekar*1, Swati C. Jagdale1, I. D. Gonjari2

    Affiliation(s) Name:

    1MAEER’s Maharashtra Institute of Pharmacy, Pune-411038, Maharashtra, India
    2Government College of Pharmacy, Karad, Maharashtra, India

    *Corresponding author.
    Ms. Varsha Babanrao Divekar,
    Department of Pharmaceutics,
    MAEER’s Maharashtra Institute of Pharmacy, MIT Campus, S.No124, Kothrud,
    Pune- 411 038, Maharashtra, India. 

    Received on:17-10-2012; Revised on: 19-11-2012; Accepted on:10-01-2013

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    Author:

    Bhanudas S. Kuchekar1, Varsha B. Divekar*1, Swati C. Jagdale1, I. D. Gonjari2

    Title:Solubility enhancement and formulation of rapid disintegrating tablet of Febuxostat Cyclodextrin complex.
    Journal:JPR:BioMedRx:An International Journal
    Vol(issue):1 (February)
    Year:2013
    Page No: (168-175)
  • Experimental Methods Keywords

    Methodology: In vitro Dissolution, Stability Testing
    Research Materials:Febuxostat

Keywords

Febuxostat βCD HPβCD superdisintegrants Cogrinding complex coevaporation complex.

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