Journal: JPR:BioMedRx:An International Journal

Article Id: JPRS-PDRS-0000263
Title: Evaluation of Anti-Alzheimer’s properties of Bacopa monniera extract on Morphometric, Behavoural aspects and Cholinergic system in albino mice
Category: Plant Drugs Related Study
Section: Research Article
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    The aim of the present study is to assess the anti-Alzheimer’s properties of Bacopa monniera plant extract (BME) on the cholinergic system of AD-induced mice. Male albino mice, Mus musculus, of one month old weighing 20±2 grams, obtained from Sri Venkateswara Enterprises, Bangalore were used as the experimental model. They were maintained in the animal house of the Department (Behringer,1973) according to the ethical guidelines for animal protection and welfare bearing the Resolution No. 02/(i)/a/CPCSEA/ IAEC/ SVU/ KY-KK/ Dt. 21-03-2011. The mice were fed with standard pellet diet and water ad libitum. The mice were divided in to four groups as follows: Group I: Control mice; Group II: mice treated with BME; Group III(AD induced): mice treated with D-Gal & NaNO2; Group IV: AD induced mice simultaneously treated with BME. Changes in Morphometric and Behavioural aspects of four groups of mice were analised by using Morris Water Maze technique. Various constituents of the cholinergic system viz., Acetylcholine (ACh) content and Acetylcholinesterase (AChE) activity were determined in selected regions of all groups of mice at selected time intervals through standard biochemical assay methods. From our results, it was ovious that BME showed positive effects on body weight, learning skills, memory and concentration, whereas D-Gal and NaNO2 caused learning and memory deficits in mice which could be ameliorated by simultaneous administration of BME. Similar protective effectsof BME were noticed on the cholinergic system of mice brain wherein , oral administration of BME could revert both the ACh content and also AChE activity to normal levels in AD induced mice. Form these observations on Morphometric and Behavioural aspects and also on the Cholinergic system it was finally concludd that BME had potential compounds which can prevent the learning and memory deficits effectively and thus confer neuroprotection againt Alzheimers Disease.

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    Author(s) Name:

    Kalyani Bai. Kunte, Peera.Kutagolla and Yellamma.Kuna*

    Affiliation(s) Name:

    Department of Zoology, Sri Venkateswara University, Tirupati- 517502,Andhra Pradesh, India.

    *Corresponding author.
    Prof. K. Yellamma
    Chairperson Board of Studies (BOS)
    Department of Zoology
    Sri Venkateswara University
    Tirupati-517501
    Andhra Pradesh,India


    Received on:17-10-2012; Revised on: 19-11-2012; Accepted on:10-01-2013

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    Author:

    Kalyani Bai. Kunte, Peera.Kutagolla and Yellamma.Kuna*

    Title:Evaluation of Anti-Alzheimer’s properties of Bacopa monniera extract on Morphometric, Behavoural aspects and Cholinergic system in albino mice
    Journal:JPR:BioMedRx:An International Journal
    Vol(issue):1 (February)
    Year:2013
    Page No: (176-187)
  • Experimental Methods Keywords

    Methodology:Evaluation of Anti-Alzheimer’s properties
    Research Materials:Bacopa monniera

Keywords

Albino mice Bacopa monniera Plant extract (BME) Alzheimer’s disease Morris Water Maze Morphometric and Behavioal aspects and Cholinergic system.

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