Journal: Drug Invention Today

Article Id: JPRS-Pcol-00002654
Title: Effect of sublingual non-steroidal anti-inflammatory drugs - ketorolac and piroxicam and its effectiveness in management of post extraction pain
Category: Pharmacology
Section: Research Article
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    Aim: The aim of the study was to examine the effect of sublingual nonsteroidal anti-inflammatory drugs (NSAIDs) in the management of post-extraction pain. Objective: The objective of the study was to compare the effects of sublingual NSAIDs in the management of post-extraction pain. Background: The surgical removal of tooth is one of the most frequently performed procedures in oral maxillofacial surgery, and afterward complications such as post-operative pain, swelling, and trismus may occur. As prostaglandins are presumed to be primary mediator of acute postsurgical inflammatory changes. NSAIDs are regarded as effective medications in the management of pain and other discomforts associated with oral surgery and exert their therapeutic effect through inhibition of cyclooxygenase, which inhibits prostaglandin production whose synergistic interactions with other mediators promote local inflammatory reactions and hyperalgesia. Materials and Methods: A clinical, double-blinded, split-mouth randomized control trial which included 25 patients undergoing extraction of maxillary premolars for orthodontic purposes was carried out. After allocation concealment and blinding, two NSAIDs piroxicam (Group A) and ketorolac (Group B) were given after extractions, and their effect on post-operative pain control was assessed using a visual analog scale ranging from 0 to 100. Results: The mean post-operative pain scale for group ketorolac was 4.54, the mean post-operative pain scale for Group B was 4.74. Statistical analysis was carried out using the Mann Whitney U-test at 5% significance. This test revealed no statistical difference between two drugs (Z = −0.18, P = 0.85). Conclusion: This study observed equal effectiveness between sublingual piroxicam and ketorolac in post-extraction pain reduction and thus can be used in clinical situations.

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    Author(s) Name:

    B. Pavithra1 , Dhanraj Ganapathy2 , Ashish R. Jain2 *

    Affiliation(s) Name:

    1 Department of Prosthodontics, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India,

    2 Department of Prosthodontics, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India

    *Corresponding author: Dr. Ashish R. Jain, Department of Prosthodontics, Saveetha Dental College and Hospital, Saveetha University, Poonamallee high road, Chennai – 600 127, Tamil Nadu, India.

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    Author:

    B. Pavithra1 , Dhanraj Ganapathy2 , Ashish R. Jain2 *

    Title:Effect of sublingual non-steroidal anti-inflammatory drugs - ketorolac and piroxicam and its effectiveness in management of post extraction pain
    Journal:Drug Invention Today
    Vol(issue):10 (December)
    Year:2018
    Page No: (2415-2418)
  • Experimental Methods Keywords

    Methodology: Nonsteroidal anti-inflammatory drugs, Post-operative pain
    Research Materials:Ketorolac, Piroxicam

Keywords

Ketorolac Piroxicam Mechanism of action Nonsteroidal anti-inflammatory drugs Post-operative pain

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