Journal: JPR:BioMedRx:An International Journal

Article Id: JPRS-SDCS-0000266
Title: Designing, structural, redox and biological investigation of copper(II), nickel(II), cobalt(II), Zinc(II) and vanadium(IV) complexes derived from 1-phenyl-2,3-dimethyl- 4-imino-(3-oxo-N-phenylbutamide
Category: Synthetic Drug Chemistry study
Section: Research Article
  • Abstract
  • Audio Abstract
  • Authors
  • Pdf File
  • Citation
  • My Reference
  • Methodology
  • Abstract

    A Schiff base namely tetradentate N2O2 donor has been prepared by condensation of acetoacetaninilido-4-aminoantipyrine and 5-(a-imino)-indole-3-propionic acid (tryptophan) in 1:1 molar ratio. Copper(II), Nickel(II), cobalt(II), Zinc(II) and VO(II) complexes of this Schiff base have been synthesized and characterized by elemental analysis, molar conductance, Magnetic measurements, IR, UV- Vis., 1H- NMR, FAB Mass, and ESR spectral data. The IR data show that the ligand is coordinated to the metal ion in a tetratendate manner with N2O2 donor site of the enolic –OH group, carboxylate oxygen and two azomethine nitrogen. Magnetic measurements and electronic spectral data of the chelates suggested that all the complexes are square planar geometry except VO(II) complex which has square pyramidal geometry. 1H-NMR spectra of the Schiff base and its zinc complex reveal that carboxylate proton of amino acid and enolic hydroxyl proton of acetoacetanilido-4- aminoantipyrine moiety were displaced during complexation. The ligand and the metal complexes were evaluated for antibacterial and antifungal activities against various bacterial and fungal strains. The results showed that all the chelate have better activity than the free ligand.

  • Abstract Audio

    Click Here

  • About the authors and Affiliations

    Author(s) Name:

    Thavuduraj Kavitha1*, Antonysamy Kulandaisamy2 and Ponnusamy Thillaiarasu3

    Affiliation(s) Name:

    1Department of Chemistry, Sri Ramasamy Naidu Memorial College, Sattur - 626203, India.
    2Department of Chemistry, Raja Doraisingam Government Arts College, Sivagangai – 630561, India.
    3Department of Chemistry, Kalasalingam University, Krishnan koil - 626190, India.

    *Corresponding author.
    Thavuduraj Kavitha
    Department of Chemistry,
    Sri Ramasamy Naidu Memorial College, Sattur - 626203, India.


    Received on:19-10-2012; Revised on: 22-11-2012; Accepted on:16-01-2013

  • View Article File in pdf format.

    Article File
  • View Article Citation Here.

    0 View More
  • How to Cite my Article.

    Author:

    Thavuduraj Kavitha1*, Antonysamy Kulandaisamy2 and Ponnusamy Thillaiarasu3

    Title:Designing, structural, redox and biological investigation of copper(II), nickel(II), cobalt(II), Zinc(II) and vanadium(IV) complexes derived from 1-phenyl-2,3-dimethyl- 4-imino-(3-oxo-N-phenylbutamide
    Journal:JPR:BioMedRx:An International Journal
    Vol(issue):1 (February)
    Year:2013
    Page No: (199-204)
  • Experimental Methods Keywords

    Methodology:Biological screening studies
    Research Materials: ligand and the metal complexes

Keywords

Biological screening studies Cyclic voltammogram ESR spectra acetoaetaninilido-4-aminoantipyrine Tryptophan.

Our Services

Most Downloaded List