Journal: JPR:BioMedRx:An International Journal

Article Id: JPRS-SDCS-0000267
Title: Assay of Some Adreno-corticosteroid Drugs with Pyridinium Fluorochromate Reagent
Category: Synthetic Drug Chemistry study
Section: Research Article
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    In the present paper, we have reported a simple and convenient titrimetric method for determination of adreno-corticosteroid drugs e.g. betamethasone sodium phosphate, dexamethasone sodium phosphate, hydrocortisone sodium succinate, prednisolone sodium succinate and triamcinolone in pure form and in their pharmaceutical preparations such as betnesol (Inj), cortil (Tab), decdon (Inj), dexasone (Tab), Primacprt (Inj), wycort (Inj), wysolone (Tab), predone forte (Syrup), tricort (Inj) and ledercort (Tab) with pyridinium fluorochromate (PFC) reagent. It is a versatile oxidizing agent of chromium (VI) and it is being increasingly used as an oxidant for several classes of organic compounds. The value of percentage error, coefficient of variation (CV) and standard deviation (SD) prove the method to be precise and reproducible. To establish authenticity of the method, recovery experiments were also carried out by standard drug addition method. It was noted that the excipients present in pharmaceutical preparations do not interfere in the estimation.

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    Author(s) Name:

    Brijesh K. Singh, Vinod Kumar and I.C.Shukla*

    Affiliation(s) Name:

    Department of Chemistry, University of Allahabad, Allahabad-211 002, India

    *Corresponding author.
    I.C.Shukla
    Department of Chemistry,
    University of Allahabad,
    Allahabad-211 002, India


    Received on:18-11-2012; Revised on: 24-12-2012; Accepted on:27-01-2013

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    Author:

    Brijesh K. Singh, Vinod Kumar and I.C.Shukla*

    Title:Assay of Some Adreno-corticosteroid Drugs with Pyridinium Fluorochromate Reagent
    Journal:JPR:BioMedRx:An International Journal
    Vol(issue):1 (February)
    Year:2013
    Page No: (205-209)
  • Experimental Methods Keywords

    Methodology:Pyridinium Fluorochromate Reagent
    Research Materials:Some Adreno-corticosteroid Drugs

Keywords

Adreno-corticosteroid drugs pharmaceutical preparations pyridinium fluorochromate oxidizing agent titration.

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