Journal: Drug Invention Today

Article Id: JPRS-TE-00002678
Title: Acute toxicity studies of Acanthus illicifolius leaves ethanolic extract on male mice
Category: Toxicity evaluation
Section: Research Article
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    Objective: The objective of this study was to evaluate the acute toxicity of ethanolic extract of Acanthus ilicifolius leaves in mice. Materials and Methods: Acute toxicity study of extracts was carried out on 20 male mice using Organization for Economic Cooperation and Development 425 guidelines. Mice divided into 4 groups, i.e. control, ethanol extract dose 1000, 2000, and 5000 mg/kg body weight (BW) by oral administration single dose of extract. Observation of toxic symptoms, BW, relative organ weight, and mortality of mice performed for 14 days. The animals were then sacrificed for blood biochemical, macro pathological and his to pathological examinations of vital organs on the end of the study. Results: Acute toxicity study results showed that male mice in all groups showed no toxic symptoms. Ethanol extract of A. ilicifolius leaves does not affect the development of BW and relative organ weight of the mouse. Histopathology of vital organs of male mice showed that the administration of ethanol extract caused changes in vital organs. The lethal dose (LD50 ) ethanol extract is >5000 mg/kg BW. Conclusion: A. ilicifolius leaves ethanol extract practically non-toxic at single dose oral administration with LD50 values >5000 mg/kg BW caused changes in some vital organs.

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    Author(s) Name:

    Dadang Irfan Husori 1 *, Popi Patilaya2 , Imam Bagus Sumantri 2 , Nuritha Elviani Khaisar1

    Affiliation(s) Name:

    1 Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan 20155, Indonesia,

    2 Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan 20155, Indonesia

    *Corresponding author: Dadang Irfan Husori, Department of Pharmacology, Laboratory of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara. Jalan Tridharma No. 5 Kampus USU Padang Bulan, Medan 20155, Indonesia.

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    Author:

    Dadang Irfan Husori 1 *, Popi Patilaya2 , Imam Bagus Sumantri 2 , Nuritha Elviani Khaisar1

    Title:Acute toxicity studies of Acanthus illicifolius leaves ethanolic extract on male mice
    Journal:Drug Invention Today
    Vol(issue):10 (December)
    Year:2018
    Page No: (2507-2513)
  • Experimental Methods Keywords

    Methodology:Acute toxicity
    Research Materials: Acanthus ilicifolius Linn

Keywords

Acanthus ilicifolius Linn Acute toxicity Ethanolic extract Jeruju

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