Journal: JPR:BioMedRx:An International Journal

Article Id: JPRS-SDCS-0000268
Title: Microwave assisted synthesis, characterization & biological evaluation of 2-(phenoxymethyl)-1-[5-(substituted aryl)-1,3,4-oxadiazole-2-yl]-1H-benzimidazoles
Category: Synthetic Drug Chemistry study
Section: Research Article
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    In an effort to develop novel 1,3,4-oxadiazoles, with various substituents characterizing and biologically screening them for anticonvulsant and antibacterial activities, a series of benzimidazole containing 1,3,4- oxadiazoles were synthesized by microwave assisted methods from presynthesized acetohydrazide by refluxing them with substituted aromatic acids at appropriate temperature in the suitably designed experimental conditions. The synthesized compounds were characterized by means of their IR, HNMR data, Mass spectrophotometry and elemental analysis. All compounds were tested for their anticonvulsant (using MES method) and antibacterial (against E. coli, S. aureus etc) activities.

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    Author(s) Name:

    Keshari Kishore Jha1*, Y. Kumar2, Mohd Shaharyar3, Sachin Singhal4

    Affiliation(s) Name:

    1Teerthanker Mahaveer University ,Muradabad,U.P.India
    2Institute of pharmaceutical Technology, ITS, Muradnagar, Ghaziabad, UP, India
    3Faculty of Pharmaceutics, Jamia Hamdard, New Delhi, India
    4NKBR College of pharmacy & Research centre, Phaphunda, Meerut, UP, India.


    *Corresponding author.
    Prof. K.K. Jha,
    410A,
    Phase-3, Tridev Park,
    Meerut-250004, India


    Received on:17-10-2012; Revised on: 19-11-2012; Accepted on:10-01-2013

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    Author:

    Keshari Kishore Jha1*, Y. Kumar2, Mohd Shaharyar3, Sachin Singhal4

    Title:Microwave assisted synthesis, characterization & biological evaluation of 2-(phenoxymethyl)-1-[5-(substituted aryl)-1,3,4-oxadiazole-2-yl]-1H-benzimidazoles
    Journal:JPR:BioMedRx:An International Journal
    Vol(issue):1 (February)
    Year:2013
    Page No: (210-216)
  • Experimental Methods Keywords

    Methodology:Microwave assisted synthesis, characterization & biological evaluation
    Research Materials:2-(phenoxymethyl)-1-[5-(substituted aryl)-1,3,4-oxadiazole-2-yl]-1H-benzimidazoles

Keywords

Microwave Benzimidazole Oxadiazole Anticonvulsant Antimicrobial activity.

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