Journal: Drug Invention Today

Article Id: JPRS-Pcol-00002688
Title: Antimycotic activity of Zingiber officinale extracts on clinical isolates of Candida albicans
Category: Pharmacology
Section: Research Article
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    Introduction: The widespread use of herbal remedies and health-care preparations. Plants produce a diverse range of bioactive molecules, making them a rich source of different types of medicines. Since ancient times, plants have been model source of medicines as they are a reservoir of chemical agents with therapeutic properties. Zingiber officinale is a flowering plant whose rhizome, ginger root or simply ginger, is widely used as a spice or folk medicine. They also have very minimal side effects and also are found in large amounts at a time and can also be easily cultivated. This makes plants a vital contributor to medicine. Materials and Methods: Candida albicans was isolated from clinical samples and cultured and maintained on Subouraud’s Dextrose Agar medium at 30°C. The ethanolic extract of Z. officinale was obtained commercially and used for the study. The extracts were prepared in the different concentrations in sterile water and were loaded on sterile filter paper The discs were dried and kept aseptically. The antimycotic activity was analyzed using disc diffusion methods. Result: The extract showed good antifungal activity at different concentrations with a maximum zone of inhibition of 21 mm at concentration of 2000 µg/ml. Conclusions: In the study, ginger extract was effective in inhibiting the growth of C. albicans. The positive control (fluconazole, amphotericin B) produced significantly sized inhibition zones with C. albicans. The study indicates that ginger extract might have promise in the treatment of oral candidiasis.

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    Author(s) Name:

    Trinaina Somas Kandhan, R. V. Geetha*

    Affiliation(s) Name:

    Department of Microbiology, Saveetha Dental College, Saveetha Institute of medical and technical sciences, Saveetha University, Chennai, Tamil Nadu, India

    *Corresponding author: R. V. Geetha, Department of Microbiology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai – 600 077, Tamil Nadu, India.

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    Author:

    Trinaina Somas Kandhan, R. V. Geetha*

    Title:Antimycotic activity of Zingiber officinale extracts on clinical isolates of Candida albicans
    Journal:Drug Invention Today
    Vol(issue):10 (December)
    Year:2018
    Page No: (2546-2549)
  • Experimental Methods Keywords

    Methodology:Antimycotic activity
    Research Materials: Zingiber officinale

Keywords

Antimycotic Candida albicans Disc diffusion Ginger Zone of inhibition

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