Journal: Drug Invention Today

Article Id: JPRS-Pcol-00002689
Title: Antibacterial action of bio nanoparticles on Streptococcus mutants and Enterococcus faecalis - An in vitro study
Category: Pharmacology
Section: Research Article
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    Introduction: Bionanotechnology combines biological principles with physical and chemical approaches to produce nano-sized particles with specific functions. These nanoparticles due to their smaller size could be very effective as they can improve the antibacterial activity through lysis of bacterial cell wall. Applications in the field of medicine include formulations of many potential antimicrobial agents that are effective against human pathogens, including multidrug- resistant bacteria which have become a serious public health problem. The aim is to study the antibacterial effects of bio nanoparticles on Streptococcus mutans and Enterococcus faecalis. Materials and Methods: The bio nanoparticles were prepared in the following concentrations in sterile water: 2.5 mg/ml, 5 mg/ml, and 10 mg/ml so that 100 µl of extract of different concentrations delivers 250 µg, 500 µg, and 1000 µg, respectively. The screening of antibacterial activity of the bio nanoparticle was carried out using the agar well diffusion method. The bacterial strain was inoculated into the nutrient broth and incubated at 37°C overnight. Mean zones of inhibition of different concentrations were measured and compared with the control and tabulated. Results: The particles showed good antibacterial activity at different concentrations with a maximum zone of inhibition of 23 mm and 19mm for Streptococcus mutans and E. faecalis, respectively, at concentration of 1000 µg/ml. Conclusion: The particles showed good antibacterial activity at different concentrations with a maximum zone of inhibition of 23 mm and 19 mm for S. mutans and E. faecalis, respectively, at concentration of 1000 µg/ml. Hence, we can conclude that silver bio nanoparticles.

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    Author(s) Name:

    C. Dharahaas, R. V. Geetha*

    Affiliation(s) Name:

    Department of Microbiology, Saveetha Dental College, Saveetha Institute of Medical andTechnical Sciences, Saveetha University, Chennai, Tamil Nadu, India

    *Corresponding author: R. V. Geetha, Department of Microbiology, Saveetha Dental College,Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.

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    Author:

    C. Dharahaas, R. V. Geetha*

    Title:Antibacterial action of bio nanoparticles on Streptococcus mutants and Enterococcus faecalis - An in vitro study
    Journal:Drug Invention Today
    Vol(issue):10 (December)
    Year:2018
    Page No: (2550-2552)
  • Experimental Methods Keywords

    Methodology: An in vitro study
    Research Materials:Bio nanoparticles

Keywords

Agar well diffusion Bio nanoparticle Enterococcus faecalis Streptococcus mutans Zone of inhibition

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