Journal: JPR:BioMedRx:An International Journal

Article Id: JPRS-SDCS-0000269
Title: Synthesis characterization and biological activities of Schiff bases of Isatin
Category: Synthetic Drug Chemistry study
Section: Research Article
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    In the present study, five new Schiff bases of Isatin were synthesized. These new compounds were formed through the condensation reaction between Isatin with 2-aminobenzoicacid, 4-aminobenzoicacid, urea, thiourea and, Pyridin-2-amine. The synthesized compound structures were characterized by FT-IR and H1NMR spectroscopy. The biological activities of the compounds were predicted by using PASS (online software for bioactivity prediction).The newly synthesized Schiff bases of , (3Z)-3-[(pyridin-2-yl)imino]-2,3-dihydro-1H-indol-2-one has shown twitching activity, Nicotinic alpha2beta2 receptor antagonist and fibrillation atrial activity. 2-{[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]amino}benzoic acid shows better activity in acute neurological disorder. [(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]thiourea acts as a best Thioredoxin inhibitor.4-{[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]amino}benzoic acid was found to have hypothermic activity.

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    Author(s) Name:

    A.AntoArockia Raj*1, J. Vinnarasi1, Dr. M .Johnson2, Dr. G.Valli3

    Affiliation(s) Name:

    1Department of chemistry, St.Xavier’s college (Autonomous), Palayamkottai, Tamil Nadu, India.
    2Department of Plant biology and Biotechnology, St.Xavier’s college (Autonomous), Palayamkottai, Tamil Nadu, India.
    3Department of chemistry, S.F.R. college for women, Sivakasi, Tamil Nadu, India.


    Received on:17-10-2012; Revised on: 19-11-2012; Accepted on:10-01-2013

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    Author:

    A.AntoArockia Raj*1, J. Vinnarasi1, Dr. M .Johnson2, Dr. G.Valli3

    Title:Synthesis characterization and biological activities of Schiff bases of Isatin
    Journal:JPR:BioMedRx:An International Journal
    Vol(issue):1 (February)
    Year:2013
    Page No: (217-222)
  • Experimental Methods Keywords

    Methodology:Synthesis characterization and biological activities
    Research Materials: Schiff bases of Isatin

Keywords

Isatin 2-aminobenzoicacid 4-aminobenzoicacid urea thiourea Pyridin-2-amine PASS.

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