Journal: Drug Invention Today

Article Id: JPRS-D(DD)-00002696
Title: Formulation and characterization of gastroretentive drug delivery system of noscapine
Category: Drug (Discovery/Development)
Section: Research Article
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    Introduction: Noscapine belongs to the class of antitussive agents and is used to treat patients suffering from a cough. Noscapine is rapidly absorbed on oral administration and has good solubility in acidic pH, but it has a very low bioavailability of nearly 30% as it undergoes hepatic first pass metabolism. Therefore, gastroretentive drug delivery system, i.e., floating tablets were designed so as to retain the dosage form in the acidic media where its solubility is more and also helps to minimize first pass effect leading to increased bioavailability of noscapine. Method: Gastroretentive floating tablets of noscapine were successfully prepared with polymers such as hydroxypropyl methylcellulose (HPMC) K4M, HPMC K100M, and hydroxyethyl cellulose (HEC). Fourier-transform infrared spectroscopy studies have shown that there is no incompatibility between the drug and the selected polymers and excipients. Noscapine floating tablets were prepared by direct compression method and are evaluated for various parameters such as weight variation, hardness, thickness, friability, swelling index, Buoyancy lag time (BLT), floating duration, and in vitro dissolution studies. Result and Discussion: The BLT of all the formulations was in the range of 35 s–1.33 min and exhibited good swelling properties over a period of time. From the in vitro dissolution analysis, it was found that the batches containing HPMC K4M and K100M showed greater release than the batches with polymer HEC. It was observed that the increasing concentration of polymers had a retarding effect on the drug release from the polymer matrices. Conclusion: Based on these evaluation results it was concluded that formulation F2 is the best formulation among all the developed formulations fulfilling the objective of the study.

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    Author(s) Name:

    Navaneetha Kaluva*, Mohammad Abdul Wahed, Mohammad Mukarram Ali Ansari, Geetha Devaraya, Krishna Mohan Chinnala

    Affiliation(s) Name:

    Department of Pharmaceutics, School of Pharmacy, Nalla Narasimha Reddy Education Society’s Group of Institutions, Hyderabad, Telangana, India

    *Corresponding author: Navaneetha Kaluva, Department of Pharmaceutics, School of Pharmacy, Nalla Narasimha Reddy Education Society’s Group of Institutions, Chowdariguda, Ghatkesar, Medchal - 500 088, Telangana, India.

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    Author:

    Navaneetha Kaluva*, Mohammad Abdul Wahed, Mohammad Mukarram Ali Ansari, Geetha Devaraya, Krishna Mohan Chinnala

    Title:Formulation and characterization of gastroretentive drug delivery system of noscapine
    Journal:Drug Invention Today
    Vol(issue):10 (December)
    Year:2018
    Page No: (2587-2592)
  • Experimental Methods Keywords

    Methodology:Bioavailability, First pass effect, Foating tablets, Gastroretentive drug delivery system
    Research Materials:Noscapine

Keywords

Bioavailability First pass effect Foating tablets Gastroretentive drug delivery system Noscapine

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