Journal: Drug Invention Today

Article Id: JPRS-Pcol-00002701
Title: The effect of ethanol on platelet count, bleeding time, and white blood cells in rats
Category: Pharmacology
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    Introduction: Alcohol consumption is suggested as a major cause of many health impairments and diseases worldwide which contributes in 15–30% of admission cases in different counties. Objective: The aim of this study is to assess the effect of alcohol on platelet counts, bleeding time, and white blood cell (WBC) count in rats. Materials and Methods: Rats were divided into five groups, each group with five rats in separate cages. Three cages were gastric lavage fed with different ethanol concentrations (15%, 20%, and 25%) continuously for 21 days, while in the rest two groups, one was control fed with water only and the other were given aspirin solution to compare with alcohol effect on bleeding. Results: The findings of the present study showed that there is significant change in bleeding time (P* > 0.05), but there is no significant change in platelet and WBC counts. Conclusion: In conclusion, alcohol may be used with caution to patients taking antiplatelet and anticoagulant drugs as alcohol is shown increasing in bleeding time; in addition, patients with immune-compromised risk should consider alcohol taking which may affect WBC mobilization rather than its count.

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    Author(s) Name:

    Shihab Hattab Mutlag1 , Ali Jabbar Abdulhussein1 *, Mohammed A. Taher2 , Amani Jabbar Hawi 1

    Affiliation(s) Name:

    1Department of Pharmacology, College of Pharmacy, University of Baghdad, Baghdad, Iraq,

    2 Department of Biochemistry, College of Pharmacy, University of Baghdad, Baghdad, Iraq

    *Corresponding author: Ali Jabbar Abdulhussein, Department of Pharmacology, College of Pharmacy, University of Baghdad, Baghdad, Iraq

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    Author:

    Shihab Hattab Mutlag1 , Ali Jabbar Abdulhussein1 *, Mohammed A. Taher2 , Amani Jabbar Hawi 1

    Title:The effect of ethanol on platelet count, bleeding time, and white blood cells in rats
    Journal:Drug Invention Today
    Vol(issue):10 (Sept [ Special Issue 1 ])
    Year:2018
    Page No: (2600-2604)
  • Experimental Methods Keywords

    Methodology:Platelet count, bleeding time, and white blood cells
    Research Materials:Ethanol

Keywords

Bleeding time and white blood cells Ethanol Platelet

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