Journal: JPR:BioMedRx:An International Journal

Article Id: JPRS-Ph-0000271
Title: Diclofenac potassium–loaded dika fat solid lipid microparticles: in vitro and in vivo characterisation
Category: Pharmaceutics
Section: Research Article
  • Abstract
  • Audio Abstract
  • Authors
  • Pdf File
  • Citation
  • My Reference
  • Methodology
  • Abstract

    The aim of the work was to formulate diclofenac potassium-loaded SLMs and evaluate the in vitro and in vivo properties of the solid lipid microparticles (SLMs). Diclofenac potassium-loaded SLMs were prepared by hot homogenization technique using admixtures of Phospholipon® 90G and dika fat (1:1, 1:2 and 2:1 %w/w) as the lipid matrix. Characterisation based on particle size, particle morphology, pH, drug content and encapsulation efficiency were carried out on the lipospheres. In vitro release was carried out in simulated intestinal fluid (SIF) without enzymes (pH 7.4) using the USP paddle method. Anti-inflammatory and ulcerogenic properties of diclofenac potassium-loaded SLMs were studied. From the results, the photomicrographs revealed spherical particles that ranged from 1.82 – 2.90 µm. SLMs formulated with lipid matrix 2:1 and containing 0.25 % diclofenac potassium had the highest encapsulation of 72 % and was significantly different from the other batches (p < 0.05). The in vitro release showed that SLMs having higher ratios of phospholipid (LM 2:1) i.e. batches C1 to C3 had more prolonged drug release rate with maximum drug release at 100 min, while SLMs formulated with lipid matrix having equal concentration of phospholipid and dika fat (A1 – A3) or having higher amount of dika fat (B1 – B3) exhibited faster release of drug with maximum drug release at 90 min. Diclofenac potassium SLMs prepared exhibited good anti-inflammatory properties and also inhibited the ulcerogenic potentials of diclofenac potassium. Therefore, diclofenac potassium-loaded SLMs exhibited good in vitro and in vivo properties.

  • Abstract Audio

    Click Here

  • About the authors and Affiliations

    Author(s) Name:

    Chime S.A.1,*, Onyishi V.I.1, Brown S.A.2, Attama A.A.3, Idogwu E.C.1, Onunkwo G.C.1

    Affiliation(s) Name:

    1Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria, Nsukka 410001, Nigeria
    2Department of Pharmaceutics and Pharmaceutical Microbiology, University of Port Harcourt, Nigeria
    3Department of Pharmaceutics, University of Nigeria, Nsukka 410001, Nigeria


    *Corresponding author.
    Chime S.A.
    Department of Pharmaceutical Technology
    and Industrial Pharmacy,
    University of Nigeria,
    Nsukka 410001, Nigeria


    Received on:17-10-2012; Revised on: 19-11-2012; Accepted on:10-01-2013

  • View Article File in pdf format.

    Article File
  • View Article Citation Here.

    0 View More
  • How to Cite my Article.

    Author:

    Chime S.A.1,*, Onyishi V.I.1, Brown S.A.2, Attama A.A.3, Idogwu E.C.1, Onunkwo G.C.1

    Title:Diclofenac potassium–loaded dika fat solid lipid microparticles: in vitro and in vivo characterisation
    Journal:JPR:BioMedRx:An International Journal
    Vol(issue):1 (March)
    Year:2013
    Page No: (227-234)
  • Experimental Methods Keywords

    Methodology:ulcerogenicity
    Research Materials:Diclofenac potassium

Keywords

Dika wax solid lipid microparticles diclofenac potassium phospholipid ulcerogenicity

Our Services

Most Downloaded List