Journal: JPR:BioMedRx:An International Journal

Article Id: JPRS-PDRS-0000276
Title: In vitro evaluation of the anthelmintic and antibacterial activities of three nigerian medicinal plants
Category: Plant Drugs Related Study
Section: Research Article
  • Abstract
  • Audio Abstract
  • Authors
  • Pdf File
  • Citation
  • My Reference
  • Methodology
  • Abstract

    The methanol extracts of the leaves of Asystasia gangetica, roots of Urtica dioica and whole plant of Spigelia anthelmia were screened for anthelmintic and antibacterial activities using in vitro models. Anthelmintic test was done using the local earthworm Nsukkadrilus mbae, while antibacterial activity against laboratory strains of Eschericia coli, Staphylococcus aureus and Bacillus subtilis were evaluated by agar diffusion technique. Extracts of the three plants caused a significant (P<0.05) concentration-related reduction in time of onset of paralysis and death of Nsukkadrilus mbae compared to piperazine. The magnitude of anthelmintic effect was in the order S. anthelmia > A. gangetica > U. dioica. In the antimicrobial activity test, only S. anthelmia inhibited microbial growth with magnitude of susceptibility in the order E. coli > S. aureus > B. subtilis, and minimum inhibitory concentrations (MIC) of 11.69, 12.59 and 14.42 mg/ml respectively. In conclusion, extracts of A. gangetica, U. dioica and S. anthelmia have significant anthelmintic activity, while S. anthelmia also possesses antibacterial activity against E. coli, S. aureus and B. subtilis.

  • Abstract Audio

    Click Here

  • About the authors and Affiliations

    Author(s) Name:

    Adaobi Chioma Ezike1*, Peter Achunike Akah1, Vincent Okore2, Charles Ogbonnaya Okoli1, Theophine Chinwuba Okoye1, Amaka Christiana Okoye1

    Affiliation(s) Name:

    1Department of Pharmacology &Toxicology, 2Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, 410001, Enugu State, Nigeria.

    *Corresponding author.
    Adaobi Chioma Ezike
    1Department of Pharmacology &Toxicology, Faculty of Pharmaceutical Sciences,
    University of Nigeria, Nsukka,
    410001, Enugu State, Nigeria.


    Received on:16-01-2013; Revised on: 28-01-2013; Accepted on:19-02-2013

  • View Article File in pdf format.

    Article File
  • View Article Citation Here.

    0 View More
  • How to Cite my Article.

    Author:

    Adaobi Chioma Ezike1*, Peter Achunike Akah1, Vincent Okore2, Charles Ogbonnaya Okoli1, Theophine Chinwuba Okoye1, Amaka Christiana Okoye1

    Title: In vitro evaluation of the anthelmintic and antibacterial activities of three nigerian medicinal plants
    Journal:JPR:BioMedRx:An International Journal
    Vol(issue):1 (March)
    Year:2013
    Page No: (254-257)
  • Experimental Methods Keywords

    Methodology:Antibacterial, Anthelminthic Activity
    Research Materials:Three nigerian medicinal plants

Keywords

Antibacterial Anthelminthic Asystasia gangetica Nsukkadrilus mbae Spigelia anthelmia Urtica dioica

Our Services

Most Downloaded List