Journal: JPR:BioMedRx:An International Journal

Article Id: JPRS-Ph-0000277
Title: Formulation and evaluation of venlafaxine hydrochloride mouth dissolving tablets by effervescent technique
Category: Pharmaceutics
Section: Research Article
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    Venlafaxine hydrochloride is used in the treatment of depression and anxiety disorders. The objective of the present study was to prepare the mouth dissolving tablets of venlafaxine hydrochloride by effervescent method. sodium bicarbonate, citric acid and tartaric acid were used as effervescent agents. Tablets are prepared by direct compression process with crosscaremellose sodium and sodium starch glycolate as super disintegrants and mannitol as bulking agent. The prepared tablets were evaluated for hardness, friability, in vitro dispersion time, weight uniformity, wetting time and for in vitro drug release. Further the tablets were characterized by Fourier Transform Infra Red Spectroscopy and by Differential Scanning Calorimetry. Among all the formulations the tablets prepared by with sodium starch glycolate as super disintegrant and tartaric acid and sodium bicarbonate as effervescent agents showed faster disintegration and rapid drug release.

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    Author(s) Name:

    R L C Sasidhar*1, S.Vidyadhara1, R. Nagaraju2, K. Satish Raj1 and E. Wilwin1

    Affiliation(s) Name:

    1. Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Guntur, A.P, India.
    2. Institute of Pharmaceutical Technology, Sri Padmavathi Mahila University, Tirupathi, A.P, India.

     

    *Corresponding author.
    R.L.C.Sasidhar
    Asst.Professor
    Chebrolu Hanumaiah Institute
    of Pharmaceutical Sciences
    Chowdavaram, Guntur-522019.
    Andhra Pradesh, India

    Received on:17-01-2012; Revised on: 25-01-2013; Accepted on:14-02-2013

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    Author:

    R L C Sasidhar*1, S.Vidyadhara1, R. Nagaraju2, K. Satish Raj1 and E. Wilwin1

    Title:Formulation and evaluation of venlafaxine hydrochloride mouth dissolving tablets by effervescent technique
    Journal:JPR:BioMedRx:An International Journal
    Vol(issue):1 (March)
    Year:2013
    Page No: (258-263)
  • Experimental Methods Keywords

    Methodology:Formulation and evaluation
    Research Materials: Venlafaxine hydrochloride.

Keywords

Venlafaxine hydrochloride. Sodium starch glycolate. Croscarmellose sodium Effervescent agents.

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