Journal: JPR:BioMedRx:An International Journal

Article Id: JPRS-Pha-0000278
Title: Toxicity testing strategies – current innovations and future outlook
Category: Pharmacology
Section: Review Article
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    Humans are often exposed to chemicals in the form of pharmaceutical substances, household products, pollutants and it is vital to screen these chemicals for their toxicity so that it can be used safely without subjecting human lives at risk. Scientific advancements in the field of toxicology paved a better platform for evaluating these chemicals. A plethora of techniques are used for this purpose which includes toxicity test using animals, in vitro testing methods for enhanced toxicity testing (cell culture systems, stem cells, toxicogenomics, in silico techniques - Toxicity database, QSARs, Human knowledge-based methods) etc. These techniques vary in their scope, use, reliability, limitations so a search is needed to find out a testing method which fulfils all aspects of a testing method. This review highlights the general toxicity testing approaches, current developments in the field of toxicology, basics and significance of alternative testing methods in toxicological research for enhanced toxicity testing.

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    Author(s) Name:

    Sharfudeen .S1*, Anusha Ganta1, P.Gowthami1, D.keerthana1, A.Prema Latha1, Sree Tej1

    Affiliation(s) Name:

    1Sir C R Reddy College of Pharmaceutical Sciences (Eluru), Andhra Pradesh, India.

    Received on:18-01-2012; Revised on: 03-02-2013; Accepted on:21-02-2013

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    Author:

    Sharfudeen .S1*, Anusha Ganta1, P.Gowthami1, D.keerthana1, A.Prema Latha1, Sree Tej1

    Title: Toxicity testing strategies – current innovations and future outlook
    Journal:JPR:BioMedRx:An International Journal
    Vol(issue):1 (March)
    Year:2013
    Page No: (264-273)
  • Experimental Methods Keywords

    Methodology:toxicity testing (cell culture systems, stem cells, toxicogenomics, in silico techniques - Toxicity database, QSARs, Human knowledge-based methods)
    Research Materials:chemical substances

Keywords

in vitro toxicogenomics in silico database QSARs.

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