Journal: Drug Invention Today

Article Id: JPRS-Pcol-00002782
Title: Cytotoxicity of SK surgical implants used for anchorage in orthodontics: In vitro study
Category: Pharmacology
Section: Research Article
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    Background: The material used for mini implants (temporary anchorage devices [TADs]) must be nontoxic and biocompatible, possess excellent mechanical properties, and provide resistance to stress, strain, and corrosion. Commonly used materials can be divided into three categories: Biotolerant (stainless steel and chromium-cobalt alloy), bioinert (titanium and carbon), and bioactive (hydroxyapatite and ceramic oxidized aluminum). Due to titanium’s characteristics (no allergic and immunologic reactions and no neoplasm formation), it is considered an ideal material and is widely used. Bone grows along the titanium oxide surface, which is formed after contact with air or tissue fluid. However, pure titanium has less fatigue strength than titanium alloys. Titanium alloy is used to overcome this disadvantage. This study was done to determine the cytotoxicity of the SK surgical mini implants, which is one of the most commonly used TADs in India due to its economic feasibility. Aim: The aim of this study is to evaluate the cytotoxicity of SK surgical implants used in orthodontics. Materials and Methods: An in vitro cytotoxicity test using indirect contact method was performed using test sample as per the ISO 10993:5. The culture medium from the L929 cell monolayer was replaced with a fresh agar medium. Test sample, control in triplicates was placed on the cells after incubation at 37 ± 1°C for 24–26 h. Monolayer was examined microscopically to determine the cytotoxic effect before and after removing the test sample from the agar medium. The reactivity was graded as 0, 1, 2, 3, and 4 based on the zone of lysis, vacuolization, detachment, and membrane disintegration. Results: This method showed that the SK surgical implants have Grade 1 cytotoxic reactivity. The viability of the cells was found to be >90%. Conclusion: From the results obtained in this study, it can be concluded that the SK surgical implant is biocompatible with Grade 1 or slightly reactive cytotoxic effects.

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    Author(s) Name:

    Suvetha Siva*, Arvind Sivakumar, Aravind Kumar, Saravana Dinesh

    Affiliation(s) Name:

    Department of Orthodontics and Dentofacial Orthopaedics, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Velappanchavadi, Chennai, Tamil Nadu, India

    *Corresponding author: Suvetha Siva, Department of Orthodontics and Dentofacial Orthopaedics, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Velappanchavadi, Chennai, Tamil Nadu, India.

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    Author:

    Suvetha Siva*, Arvind Sivakumar, Aravind Kumar, Saravana Dinesh

    Title:Cytotoxicity of SK surgical implants used for anchorage in orthodontics: In vitro study
    Journal:Drug Invention Today
    Vol(issue):10 (October [ Special Issue 2 ])
    Year:2018
    Page No: (2927-2929)
  • Experimental Methods Keywords

    Methodology: in vitro cytotoxicity test
    Research Materials:stainless steel and chromium-cobalt alloy

Keywords

Anchorage Biocompatibility Cytotoxicity Mini-implants SK Surgical implants

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