Journal: Drug Invention Today

Article Id: JPRS-Pcol-00002787
Title: Voltammetric and flow injection amperometric determination of insulin, uric acid, and ascorbic acid at the electrode modified by iridium oxides
Category: Pharmacology
Section: Research Article
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    Aim: Mixed valence oxides of iridium, immobilized on surface of carbon electrodes by potentiodynamic electric sedimentation demonstrate electric catalytic activity and oxidation of insulin, uric acid (UA), and ascorbic acid. This leads to the reduction of overvoltage of considered compounds oxidation and increasing of their oxidation current relatively to current of modifier oxidation. Materials and Method: Possibility of jointed voltammetric determination of insulin, UA, and ascorbic acid on glassy carbon electrode modified by iridium oxides (IrOx s) is established. Difference of potentials of these compounds oxidation peaks is 300 mV. Method of flow injection amperometric determination of insulin and UA on dual planar electrode modified by IrOx s is proposed. Results: Linear dependence of analytic signal from concentration of organic compounds is observed in interval of 5 × 10−8 to 5 × 10−4 М for insulin and of 5 × 10−7 –5 × 10−3 М for UA. Developed method of flow injection amperometric determination on insulin and UA is distinguished by high sensitivity, repeatability, as well as rapidity, and productivity of analysis method (up to 480 determinations per hour). Conclusion: Proposed method was used for the determination of insulin and UA in human saliva.

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    Author(s) Name:

    Shaidarova Larisa Gennadievna*, Il’vina A. Abzalova, Irina A. Chelnokova, Anna V. Gedmina, German K. Budnikov

    Affiliation(s) Name:

    Department of Analytical Chemistry, Alexander Butlerov Institute of Chemistry, Kazan Federal Universit, Kazan, Russia

    *Corresponding author: Shaidarova Larisa Gennadievna, Department of Analytical Chemistry, Alexander Butlerov Institute of Chemistry, Kazan Federal Universit, Kazan, Russia.

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    Author:

    Shaidarova Larisa Gennadievna*, Il’vina A. Abzalova, Irina A. Chelnokova, Anna V. Gedmina, German K. Budnikov

    Title:Voltammetric and flow injection amperometric determination of insulin, uric acid, and ascorbic acid at the electrode modified by iridium oxides
    Journal:Drug Invention Today
    Vol(issue):10 (October [ Special Issue 2 ])
    Year:2018
    Page No: (2949-2953)
  • Experimental Methods Keywords

    Methodology: voltammetric determination
    Research Materials:Insulin, uric acid, and ascorbic acid

Keywords

Chemically modified electrode Dual planar electrode Electric oxidation of insulin Flow injection analysis of human saliva Iridium oxides Uric acid and ascorbic acid

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