Journal: JPR:BioMedRx:An International Journal

Article Id: JPRS-Ph-0000279
Title: Formulation development and evaluation of terbutaline sulphate mucoadhesive buccal tablets
Category: Pharmaceutics
Section: Research Article
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    Mucoadhesive drug delivery system is bind to the gastric mucin or epithelial cell surface are useful in drug delivery for increasing the intimacy and duration of contact of drug with the absorbing membrane, this helps in sustained release of drug and prevent the metabolism of drug in gastric pH condition for the drug sensitive for acidic condition. In this work, the attempt has made to develop and evaluate the Mucoadhesive Buccal tablets of Terbutaline sulphate with natural polymers gaur gum, with ethyl cellulose as back layer of bilayer tablets. Terbutaline sulfate is a white to gray-white crystalline powder. It is odorless or has a faint odor of acetic acid. Terbutaline sulfate is indicated in for the prevention and reversal of bronchospasm in patients 12 years of age and older. With asthma, COPD and reversible bronchospasm associated with bronchitis and emphysema. Because of its first pass metabolism its bioavailability is in the range of 30 to 50% by orally. I R Spectroscopy did the compatible study between polymers and Terbutaline sulphate and No interaction was found between drug and polymers. Different formulations of oral Mucoadhesive buccal tablets of Terbutaline Sulphate (TS) were prepared using polymer Gaur gum, in different concentrations by direct compression. Post compressed evaluation studies, hardness, thickness, friability; weight variation and drug content, mucoadhesive strength of tablets were studied. The in-vitro release of TS was studied in buffer pH 6.8 at 370C. All parameters of TS buccal tablets are passed the standard of mucoadhesive buccal tablets. It was found that mucoadhesive natural polymers exhibited better adhesiveness and mucoadhesiveness. The in vitro study of TS exhibited greater drug release profile with release of in the range of 80.57 to 100.81%.

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    Author(s) Name:

    Gururaj S.Kulkarni1a, 1b*, N.G RaghavendraRao2, Upendra. Kulkarni3

    Affiliation(s) Name:

    1aResearch Scholar of Singhania University, Pacheri Bari. Jhunjhunu, Rajasthan, India
    1bVivekananda College of Pharmacy, Rajaji Nagar, Bangalore,Karnataka, India
    2 Dept of Pharmaceutics, Jyothishmathi Institute of Pharmaceutical Science, Karimnagar,Karnataka, India.
    3R.M.E’S College of Pharmacy, Gulbarga,Karnataka, India

    *Corresponding author.
    Gururaj S.Kulkarni,
    Vivekananda College of Pharmacy,
    Rajaji Nagar,
    Dr. Rajkumar road,
    Bangalore-560055,Karnataka, India


    Received on:17-01-2012; Revised on: 03-02-2013; Accepted on:27-02-2013

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    Author:

    Gururaj S.Kulkarni1a, 1b*, N.G RaghavendraRao2, Upendra. Kulkarni3

    Title:Formulation development and evaluation of terbutaline sulphate mucoadhesive buccal tablets
    Journal:JPR:BioMedRx:An International Journal
    Vol(issue):1 (March)
    Year:2013
    Page No: (274-279)
  • Experimental Methods Keywords

    Methodology:mucoadhesive buccal tablets
    Research Materials:terbutaline sulphate

Keywords

Buccal tablets in-vitro Gaur gum pH COPD TS Gaur gum.

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